Synthesis and in vitro Antisickling Activity of Some Non-aromatic Esters

Dorothée D. Tshilanda; Koto-Te-Nyiwa Ngbolua; Damien S. T. Tshibangu; Augustin M. Malumba; Pius T. Mpiana

doi:10.9734/ACSJ/2016/22734

Research Article Open access CC BY 4.0

Synthesis and in vitro Antisickling Activity of Some Non-aromatic Esters

Dorothée D. Tshilanda, Koto-Te-Nyiwa Ngbolua, Damien S. T. Tshibangu, Augustin M. Malumba, Pius T. Mpiana

Chemical Science International Journal · pp. 1–5 · Published 27 Nov 2015

10.9734/ACSJ/2016/22734

Abstract

Organic acids and their derivatives like butyl stearate have recently shown antisickling activity. Some none aromatic esters were synthetized and tested for their antisickling activity using Emmel test. On 21 esters tested only three showed no antisickling activity. Butyl palmitate, propyl palmitate, butyl stearate, propyl stearate and methyl nonadecanoate showed interesting antisickling activity with a normalization rate higher than 70%.

Non- aromatic esters antisickling activity synthesis butyl stearate

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Dorothée D. Tshilanda, Koto-Te-Nyiwa Ngbolua, Damien S. T. Tshibangu, Augustin M. Malumba, Pius T. Mpiana (2015). Synthesis and in vitro Antisickling Activity of Some Non-aromatic Esters. Chemical Science International Journal , 1–5. https://doi.org/10.9734/ACSJ/2016/22734

Affiliations

Dorothée D. Tshilanda — Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
Koto-Te-Nyiwa Ngbolua — Department of Biology, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
Damien S. T. Tshibangu — Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
Augustin M. Malumba — Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
Pius T. Mpiana — Department of Chemistry, Faculty of Science, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo

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Synthesis and in vitro Antisickling Activity of Some Non-aromatic Esters

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