Pius T. Mpiana, Koto-Te-Nyiwa Ngbolua, Damien S. T. Tshibangu, Jason T. Kilembe, Benjamin Z. Gbolo, Domaine T. Mwanangombo, Clément L. Inkoto, Emmanuel M. Lengbiye, Clément M. Mbadiko, Aristote Matondo, Gédéon N. Bongo & Dorothée D. Tshilanda·European Journal of Medicinal Plants·2020
Aims: A novel β-coronavirus (2019-nCoV) has become a pandemic affecting hundreds of thousands of people worldwide. Since there is no effective treatment, the need of finding alternative methods which can help to curb this pandemic is urgent. This study aims to review the literatu...
Open access
Research Article10.9734/ejmp/2020/v31i830261
Kazadi Minzangi, Pius T. Mpiana, Bashwira Samvura, Archileo N. Kaaya, Matthäus Bertrand & Justin N. Kadima·European Journal of Medicinal Plants·2015
Objective: Kahuzi-Biega National Park (KBNP) in Democratic Republic of the Congo is packed with fantastic oilseed plants that need to be analysed in order to promote a sustainable exploitation for both commercial and food supply purposes. The study aimed to determine the content...
Open access
Research Article10.9734/EJMP/2015/17297
Clément M. Mbadiko, Koto-Te-Nyiwa Ngbolua, Pius T. Mpiana, Nadège K. Ngombe, Paulin M. Kapepula, Landry L. Kemfine, Gédéon N. Bongo & Théophile F. Mbemba·South Asian Research Journal of Natural Products·2019
Aims: The aim of this research was to evaluate comparatively the anti-sickling activity of aqueous and methanol extracts of different organs of C. longa, to determine the polyphenolic compounds and to evaluate the antioxidant potential of different parts of C. longa. Also, to est...
Organic acids and their derivatives like butyl stearate have recently shown antisickling activity. Some none aromatic esters were synthetized and tested for their antisickling activity using Emmel test. On 21 esters tested only three showed no antisickling activity. Butyl palmita...
Open access
Research Article10.9734/ACSJ/2016/22734
Odette N. Kabena, Naomie E. Nyakembe, Jean Jacques D. Amogu, Lionel S. Asamboa, Emmanuel M. Lengbiye, Justin E. Mboloko, Pius T. Mpiana & Félicien L. Lukoki·European Journal of Medicinal Plants·2020
Aim: The aim of this work is to evaluate the spermicidal, antimicrobial activity of Oncoba welwitchii Oliv. This will justify its use on reproductive health especially in the occurrence of infertility and the imbalance of vaginal flora. Carried out at the Department of Biology of...
Open access
Research Article10.9734/ejmp/2020/v31i1730336
Samy Ngunde-Te-Ngunde, Kabengele N. Carlos, Emmanuel Moke Lengbiye, Jason Thambwe Kilembe, Jean-Aimé Mbanga Lokebo, Dorothée D. Tshilanda, Nadège Kabamba Ngombe, Pius T. Mpiana, Jeff Iteku Bekomo & Koto-Te-Nyiwa Ngbolua·Annual Research & Review in Biology·2022
Aims of the Study: To identify plant species traditionally used to treat anemia in Yakoma territory and to evaluate their chemical composition. Place and Duration: Yakoma Territory (survey) and University of Kinshasa (Phytochemical study), from August and October 2019. Methods: E...
Open access
Research Article10.9734/arrb/2022/v37i430498
Clément L. Inkoto, Koto-Te-Nyiwa Ngbolua, Patrick E. Bokungu, Colette A. Masengo, Jeff B. Iteku, Dorothée D. Tshilanda, Damien S. T. Tshibangu & Pius T. Mpiana·South Asian Research Journal of Natural Products·2021
According to the World Health Organization (WHO), more than 80% of the population in Africa in general and in the Democratic Republic of the Congo (DRC) in particular, resorts to Traditional Medicine to solve the problem of primary health care. In this study we had reviewed the r...
Clément L. Inkoto, Koto-Te-Nyiwa Ngbolua, Jason T. Kilembe, Colette Masengo Ashande, Félicien L. Lukoki, Dorothée D. Tshilanda, Damien S-T. Tshibangu & Pius T. Mpiana·South Asian Research Journal of Natural Products·2021
Background and Aims: Given the importance of finding a new Improved Traditional Medicine (ITM) based on medicinal plants, we reviewed the traditional uses, phytochemical composition, biological properties and toxicity of Aframomum alboviolaceum (Zingiberaceae), a plant species wi...
Beaudrique M. Nsimba, Norbert L. Basosila, Jean-Claude K. Kayembe, Didier M. Mbuyi, Aristote P. Matondo, Gédéon N. Bongo, Koto-Te-Nyiwa Ngbolua & Pius T. Mpiana·Asian Journal of Applied Chemistry Research·2020
In this work, a semi-empirical approach correlating the values of methanogenic toxicity of 22 aromatic compounds was used. TheIC50 exp, along with the various molecular properties of these compounds were determined using the DFT B3LYP/6-31G (d,p) method. While a conceptual appro...
Open access
Research Article10.9734/ajacr/2020/v5i430146
Aim: The aim of this study is to evaluate clinical, biological, socio-economic and socio-demographic parameters on sickle cell patients before, during and after the administration of Drepanoalpha®, a nutraceutical used in the management of sickle cell disease in DR. Congo. Method...
Open access
Research Article10.9734/JOCAMR/2017/37350
Aims: The aim of this study is to assess the efficacy and safety of Drepanoalpha®, a nutraceutical used in the management of sickle cell disease in DR Congo. Study Design: Drepanoalpha® to ten sickle patients, evaluation of parameters before and after treatment. Place and Duratio...
Open access
Research Article10.9734/IJMPCR/2017/33658
Carlos N. Kabengele, Giresse N. Kasiama, Etienne M. Ngoyi, Jason T. Kilembe, Juvenal Bete, Damien S. T. Tshibangu, Koto-Te-Nyiwa Ngbolua, Dorothée D. Tshilanda & Pius T. Mpiana·Annual Research & Review in Biology·2022
Background and Aims: Manotes expansa Sol. ex Planch. and Aframomum alboviolaceum (Ridl.) Schum. are two plants belonging respectively to the family Connaraceae R.Br. and Zingiberaceae Martino widely used in traditional medicine for the treatment of eye diseases, fever, headaches...
Open access
Research Article10.9734/arrb/2022/v37i1130549
Koto-Te-Nyiwa Ngbolua, Clément L. Inkoto, Gédéon N. Bongo, Lengbiye E. Moke, Lufuluabo G. Lufuluabo, Colette Masengo Ashande, Damien S. T. Tshibangu, Dorothée D. Tshilanda & Pius T. Mpiana·South Asian Research Journal of Natural Products·2018
Aims: To provide knowledge on phytochemistry and bioactivity of Annona reticulata. Study Design: Multidisciplinary advanced bibliographic surveys, utilization of ChemBioDraw software package and dissemination of the resulted knowledge. Place and Duration of Study: Faculty of Scie...
Damien S. Tshibangu, Selvaraj Divakar, Muthiah Ramanathan, Govindarajan G. Syamala, Koto-Te-Nyiwa Ngbolua, Virima Mudogo, Dorothée D. Tshilanda, Benjamin Z. Gbolo & Pius T. Mpiana·Journal of Complementary and Alternative Medical Research·2016
Aim: The aim of the study is to evaluate the cytotoxicity of the crude extracts of Gardenia ternifolia (Oliv.) in human prostate cancer (PC-3) and breast cancer (MCF-7) cell lines. Study Design: Successive extractions of Gardenia ternifolia leaves were performed, using petroleum...
Open access
Research Article10.9734/JOCAMR/2016/28348
Kazadi Minzangi, Justin N. Kadima, Archileo N. Kaaya, Bertrand Matthäus, Patrick Van Damme, Bashwira Samvura, Dieudonné E. Mosibono, Katula Belesi & Pius T. Mpiana·European Journal of Medicinal Plants·2015
Aims: Most natural oils only have limited application in their crude forms, but fractionation can provide a variety of food applications. The objective was to fractionate crude oils from five selected plants growing wild in Kahuzi-Biega National Park (KBNP) in DR Congo, to analy...
Open access
Research Article10.9734/EJMP/2015/19653
Masengo Ashande Colette, Emmanuel Lengbiye Moke, Clément Inkoto Liyongo, Benjamin Zoawe Gbolo, Dorothée Dinangayi Tshilanda, Damien Sha-Tshibey Tshibangu, Robijaona Rahelivololoniaina Baholy, Ilumbe Bayeli Guy, Koto-Te-Nyiwa Ngbolua, Pius T. Mpiana & Mudogo Virima·South Asian Research Journal of Natural Products·2021
Background: Lippia multiflora is a wild/spontaneous food plant with numerous pharmaco-therapeutic activities and rich in terpenic and phenolic bioactive compounds whose valorization as nutaceutical can help a better management of chronic diseases. Objective: To make an inventory...
Jules M. Kitadi, Clément L. Inkoto, Emmanuel M. Lengbiye, Damien S. T. Tshibangu, Dorothée D. Tshilanda, Koto-Te-Nyiwa Ngbolua, K. M. Taba, Blaise M. Mbala, Brigitte Schmitz & Pius T. Mpiana·International Blood Research & Reviews·2020
Aims: To determine the mineral composition of some plants (Annona senegalensis Pers., Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg. and Vigna unguiculate (L.) Walp.) used in the management of sickle cell disease by traditional practitioners in Kwilu province and to eva...
Open access
Research Article10.9734/ibrr/2020/v11i330131
Mfutu Mana Charly, Sekele Issouradi Jean-PauI, Koto-Te-Nyiwa Ngbolua, Situakibanza Nani-Tuma Hippolyte, Kamangu Ntambwe Erick, Paul Bobe Alifi, Nzudjom Foche Adelin, Monizi Mawunu, Emmanuel Kitete Mulongo, Tukutuku Musombo Nanou Anne, Pius T. Mpiana & Pakasa Muyulu Nestor·Annual Research & Review in Biology·2022
Oral cavity cancers are part of the upper aerodigestive tract cancers and represent a significant burden worldwide. Its epidemiology varies from country to country with high frequencies in South East Asian countries. Tobacco and alcohol are the main risk factors. Survival of oral...
Open access
Research Article10.9734/arrb/2022/v37i630512
Rita Bokemposila, Clément L. Inkoto, Alexis Kazamwali, Gaston Mwema, Christian Lobinga, Louise Malonga, Jean Claude Malenga, Thérèse Mbeza, Jean Lambert Gini Ehungu, Koto-Te-Nyiwa Ngbolua & Pius T. Mpiana·International Journal of Research and Reports in Hematology·2021
Neonatal infection (NI) remains a public health problem of concern because of its frequency and severity, which is related to the immuno-incompetence of the newborn and the risk of mortality, which is in the order of 10% to 30%. According to the World Health Organization (WHO), 3...
Blaise Mbembo Wa Mbembo, Colette Masengo Ashande, Lionel Asamboa Shotsha, Samy Ngunde Te Ngunde, Blanchard Mayele Masasi, Joseph Tshidibi Dipa, Sylvain Zogi Ngbo, Jean-Jacques Amogu Domondo, Dorothée D. Tshilanda, Damien S. T. Tshibangu, Pius T. Mpiana & Koto-Te-Nyiwa Ngbolua·Journal of Complementary and Alternative Medical Research·2021
Medicinal plants are suppliers of molecules used in both modern and traditional therapy. One of these plants is Azadirachta Indica (also known as the neem tree).Originally from Asia (India), this plant is currently widespread and cultivated in several countries in the world, incl...
Open access
Research Article10.9734/jocamr/2021/v15i230261
Adam A. Ikey, Giresse N. Kasiama, Carlos N. Kabengele, Michel L. Kapembo, Etienne N. Matshimba, Juvenal Bete, Jason T. Kilembe, Clément L. Ikoto, K. N. Ngbolua, Damien S. T. Tshibangu, Dorothée D. Tshilanda & Pius T. Mpiana·International Journal of Pathogen Research·2022
Aims: The objective of this study was to determine the phytochemical profile of Centella asiatica, Citrus grandis and Zanthoxylum gilletii leaves, in solution and the thin layer chromatography chemical screening and to evaluate the antibacterial photodynamic activity of the speci...
Open access
Research Article10.9734/ijpr/2022/v9i230219
Florent Biduaya Mukeba, Myriam Mukadi Ngondo, Nazaire Kabemba Kadima, Prince Bofati Ilonga, Patrick Kayembe Bibasuya, Patience Mpia Ngelinkoto, Paulin Kapepula Mutwale, Koto-Te-Nyiwa Ngbolua, Kalima Nkoma Mwange, Johnny Bopopi Mukoko, Nadège Kabamba Ngombe, Pius T. Mpiana & Théophile Mbemba Fundu·Asian Journal of Environment & Ecology·2021
Aim: The aim of this study was to compare the texture, mineral element and heavy metal content of the soil under the litter of different selected species in relation to the plan of their pedogenesis. Methods: The granulometric analysis of the various samples based on laser diffra...
Open access
Research Article10.9734/ajee/2021/v14i330208
Florent Biduaya Mukeba, Johnny Bopopi Mukoko, Manix M. Mayangi, Myriam Mukadi Ngondo, Patience Mpia Ngelinkoto, Jérome V. Bamba, Fanfan Kitwa, Gédéon Ngiala Bongo, Paulin K. Mutwale, Koto-Te-Nyiwa Ngbolua, Nadège K. Ngombe, Pius T. Mpiana & Théophile F. Mbemba Mbemba·European Journal of Medicinal Plants·2020
Aims: This study addressed the identification of bioactive compounds, the determination of mineral content and the evaluation of the antibacterial, antioxidant and anti-sickling activities of aqueous extract from stem bark of Harungana madagascariensis. Place and Duration of Stud...
Open access
Research Article10.9734/ejmp/2020/v31i2030355
Giresse N. Kasiama, Adam Ikey, Carlos N. Kabengele, Jason T. Kilembe, Etienne N. Matshimba, Juvenal M. Bete, Prudent B. Bahati, Clément L. Inkoto, Paulin K. Mutwale, K. N. Ngbolua, Damien S. T. Tshibangu, Dorothée D. Tshilanda & Pius T. Mpiana·Annual Research & Review in Biology·2022
Aim: The objective of this study was to determine the phytochemical profile of Senna alata LINN using chemical screening in solution and thin-layer chromatography, and to assess the antioxidant and anthelmintic activities of the plant’s aqueous extracts. Methodology: All the anal...
Open access
Research Article10.9734/arrb/2022/v37i630513
Aristote Matondo, Jason T. Kilembe, Domaine T. Mwanangombo, Beaudrique M. Nsimba, Dani T. Mawete, Benjamin Z. Gbolo, Gédéon N. Bongo, D. O. Opota, Koto-Te-Nyiwa Ngbolua, Dorothée D. Tshilanda, Damien S. T. Tshibangu, Virima Mudogo & Pius T. Mpiana·Journal of Complementary and Alternative Medical Research·2021
Aim: In the most severe case of the COVID-19, there is an excessive production of proinflammatory cytokines, being the main cause of mortality and morbidity. The present study aims at assessing the potential inhibitor effect of six phytochemicals with anti-inflammatory activity d...
Open access
Research Article10.9734/jocamr/2020/v12i330211
Koto-Te-Nyiwa Ngbolua, Clément M. Mbadiko, Aristote Matondo, Gédéon N. Bongo, Clément L. Inkoto, Benjamin Z. Gbolo, Emmanuel M. Lengbiye, Jason T. Kilembe, Domaine T. Mwanangombo, Etienne M. Ngoyi, Clarisse M. Falanga, Damien S. T. Tshibangu, Dorothée D. Tshilanda & Pius T. Mpiana·European Journal of Nutrition & Food Safety·2020
Background and Aim: Condiment plants are not only a source of food, flavors or food additives but also antivirals. The aim of the present work consisted in compiling ethno-botanical, phytochemical, toxicological and biological activities literature data reported on some species o...
Open access
Research Article10.9734/ejnfs/2020/v12i730246
Clément M. Mbadiko, Clément L. Inkoto, Benjamin Z. Gbolo, Emmanuel M. Lengbiye, Jason T. Kilembe, Aristote Matondo, Domaine T. Mwanangombo, Etienne M. Ngoyi, Gédéon N. Bongo, Clarisse M. Falanga, Damien S. T. Tshibangu, Dorothée D. Tshilanda, Koto-Te-Nyiwa Ngbolua & Pius T. Mpiana·Journal of Complementary and Alternative Medical Research·2020
Background: Plants of the Zingiberaceae family namely Curcuma longa, Aframomum melegueta and Zingiber officinale are known for their many biological activities such as the antiviral activity. Aim: To provide an updated knowledge on the phytochemistry, toxicology and antiviral act...
Open access
Research Article10.9734/jocamr/2020/v9i430150
Dorothée D. Tshilanda, Etienne M. Ngoyi, Carlos N. Kabengele, Aristote Matondo, Gédéon N. Bongo, Clément L. Inkoto, Clément M. Mbadiko, Benjamin Z. Gbolo, Emmanuel M. Lengbiye, Jason T. Kilembe, Domaine T. Mwanangombo, Giresse N. Kasiama, Damien S. T. Tshibangu, Koto-Te-Nyiwa Ngbolua & Pius T. Mpiana·International Journal of Pathogen Research·2020
Aim: The aim of this work was to review literature data reported on some species of the Ocimum genus regarding their phytochemistry and antiviral potential in order to show how Ocimum species might be used in the management of COVID-19. Methodology: Various databases like PubMed,...
Open access
Research Article10.9734/ijpr/2020/v5i430143
Carlos N. Kabengele, Etienne M. Ngoyi, Giresse N. Kasiama, Jason T. Kilembe, Aristote Matondo, Clément L. Inkoto, Emmanuel M. Lengbiye, Clément M. Mbadiko, Jean Jacques D. Amogu, Gédéon N. Bongo, Benjamin Z. Gbolo, Damien S. T. Tshibangu, Koto-Te-Nyiwa Ngbolua, Dorothée D. Tshilanda & Pius T. Mpiana·Asian Journal of Biology·2020
Aim: The main aim of the present study is to validate the bioactivity of O. basilicum, a medicinal plant traditionally used to treat helminthiasis in DRC. Place and Duration of Study: Department of Chemistry, Science Faculty, University of Kinshasa, between June 2018 and March 20...
Open access
Research Article10.9734/ajob/2020/v10i330110
Damien S. T. Tshibangu, Aristote Matondo, Emmanuel M. Lengbiye, Clément L. Inkoto, Etienne M. Ngoyi, Carlos N. Kabengele, Gédéon N. Bongo, Benjamin Z. Gbolo, Jason T. Kilembe, Domaine T. Mwanangombo, Clément M. Mbadiko, Shetonde O. Mihigo, Dorothée D. Tshilanda, Koto-Te-Nyiwa Ngbolua & Pius T. Mpiana·Journal of Complementary and Alternative Medical Research·2020
Aim: Till now, no specific treatment is available for COVID-19. This work is carried out with the aim of verifying in the literature the antiviral properties of aromatic plants and essential oils that can justify their use against the causative agent of COVID-19, SARS-CoV-2. Meth...
Open access
Research Article10.9734/jocamr/2020/v11i130175
Emmanuel M. Lengbiye, Clément M. Mbadiko, Clarisse M. Falanga, Aristote Matondo, Clément L. Inkoto, Etienne M. Ngoyi, Carlos N. Kabengele, Gédéon N. Bongo, Benjamin Z. Gbolo, Jason T. Kilembe, Domaine T. Mwanangombo, Damien S. T. Tshibangu, Dorothée D. Tshilanda, Shetonde O. Mihigo, Koto-Te-Nyiwa Ngbolua & Pius T. Mpiana·International Journal of Pathogen Research·2020
Aims: COVID-19 pandemic affects hundreds of thousands of people worldwide. Since there is no effective treatment, the need of finding alternative methods, which can help to curb this pandemic is urgent. This study aims to collect the information on the virucidal and toxicity prop...
Open access
Research Article10.9734/ijpr/2020/v5i430145
Aristote Matondo, Jason T. Kilembe, Etienne M. Ngoyi, Carlos N. Kabengele, Giresse N. Kasiama, Emmanuel M. Lengbiye, Clément M. Mbadiko, Clément L. Inkoto, Gédéon N. Bongo, Benjamin Z. Gbolo, Clarisse M. Falanga, Domaine T. Mwanangombo, Daniel O. Opota, Damien S. T. Tshibangu, Dorothée D. Tshilanda, Koto-Te-Nyiwa Ngbolua & Pius T. Mpiana·International Journal of Pathogen Research·2021
Aim: The present study aims at identifying potential inhibitors from a set of ten compounds from Ocimum basilicum against the SARS-CoV-2 main protease, the chymotrypsin-like protease (3CLpro). Materials and Methods: Computational studies by molecular docking (Autodock tool) were...
Open access
Research Article10.9734/ijpr/2021/v6i230156