Background: Duodenal villous atrophy in a patient with chronic mesenteric ischaemia presents a diagnostic challenge because vascular insufficiency and enteropathy may produce overlapping gastrointestinal manifestations. Case Presentation: We describe a 43-year-old man with chroni...
Open access
Research Article10.9734/irjgh/2026/v9i1162
Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major causes of chronic liver disease and are associated with complex host immune and inflammatory responses. Interleukin-6 (IL-6) is an important pro-inflammatory cytokine involved in immune regulatio...
Open access
Research Article10.9734/irjgh/2026/v9i1160
Background: Non-linear models, unequal (random) estimation uncertainty, repeated observations, and temporal autocorrelation are not adequately addressed in conventional liver-burden studies, which typically use percentage changes or linear annual trends. The purpose of this study...
Open access
Research Article10.9734/irjgh/2026/v9i1161
Aim: To investigate the time-dependent effects of activated charcoal on cytochrome P450 (CYP2E1) activity, oxidative stress (SOD), liver injury enzymes (AST, ALT, ALP, and GGT), and hepatic function parameters (total protein, albumin, and total bilirubin) in albino rats exposed t...
Open access
Research Article10.9734/irjgh/2026/v9i1159
Non-cirrhotic portal hypertension is an uncommon cause of variceal bleeding and requires careful evaluation for vascular, hepatic, infectious, autoimmune, metabolic, and haematological causes. Chronic myelomonocytic leukaemia is a clonal haematological malignancy characterised by...
Open access
Research Article10.9734/irjgh/2026/v9i1158
Leptospirosis is a bacterial zoonosis that may rarely cause severe hepatic involvement and fulminant acute liver failure. We report a 32-year-old man with no notable medical history who presented after seven days of fever, intense myalgia, headache, and vomiting, with recent expo...
Open access
Research Article10.9734/irjgh/2026/v9i1157
Wernicke encephalopathy is an acute neurological disorder caused by thiamine deficiency and is often under-recognised in patients without chronic alcohol misuse. Prolonged vomiting and impaired nutritional intake may rapidly deplete thiamine stores and precipitate neurological de...
Open access
Research Article10.9734/irjgh/2026/v9i1155
Ibrahim Hussain Alzahib, Ensaf Adnan Mousa AlBokhari, Khalid Hazim A. Alotaibi, Mashael Zayed M. AlBalawi, Bader Abdulrahman Husayyan Alanazi, Metab Ali Saeed Alasmari, Mohammed Hussain Abdulrahman Alzahib & Norah Saad Jubran Alkahtani·International Research Journal of Gastroenterology and Hepatology·2026
Background: Metabolic dysfunction-associated steatohepatitis (MASH), formerly termed nonalcoholic steatohepatitis, can progress to advanced fibrosis, cirrhosis, hepatic decompensation, hepatocellular carcinoma, transplantation, and death. Resmetirom and semaglutide have reached c...
Open access
Research Article10.9734/irjgh/2026/v9i1156
Background: Alcoholic hepatitis (AH) is a serious medical condition with limited treatment options and significant short-term mortality risk. While S‑adenosyl methionine (SAMe) and ursodeoxycholic acid (UDCA) individually exhibit hepatoprotective properties, their combination rem...
Open access
Research Article10.9734/irjgh/2026/v9i1154
Aims: Capsule endoscopy (CE) has become an essential diagnostic tool for small-bowel evaluation. Despite its high diagnostic yield and safety profile, technical limitations and clinical complications may affect its performance. This study aimed to evaluate the diagnostic performa...
Open access
Research Article10.9734/irjgh/2026/v9i1153