Assessing the Antidiabetic Properties of Methanolic extract of Baccaurea motleyana leaf in Alloxan-induced Diabetic Mice
Md. Atiq Ashhab, Md. Monirul Islam, Md. Muhaimanul Haque, Md. Sohan Ahmed, Md. Mehebub Al Raji, Mokhleshur Rohman, Zakia Sultana Juthi, Mohammad Amirul Islam
Asian Journal of Biochemistry, Genetics and Molecular Biology · pp. 30–37 · Published 15 Feb 2025
10.9734/ajbgmb/2025/v17i3447Abstract
Background: Medicines made from Baccaurea motleyana are used to treat a wide range of illnesses. The current study targeted to investigate the methanolic extract of Baccaurea motleyana leaf's antidiabetic qualities. Results: The leaf extract of Baccaurea motleyana at a concentration of 100μg/ml, the α-amylase activity was found to be 37.01% inhibited and the α-glucosidase activity to be 55.05% inhibited in the α-amylase inhibition experiment. The leaf extract considerably (P < 0.05) reduced blood glucose levels and improved lipid profile levels such as (TG, LDL, TC, VLDL & HDL) in diabetic mice, based on the findings of antidiabetic tests conducted in in-vivo. When compared to diabetic animals that were not treated, treatments with the extract of methanol of Baccaurea motleyana leaf for 24 days significantly (P < 0.05) decreased the effects of the ALT and AST enzymes in the diabetic mice (alloxan induced) also. Conclusion: According to this study, the leaf extract of Baccaurea motleyana has strong antidiabetic effects. Because of this, they may be able to help avoid diabetes mellitus and its complications.
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