Therapeutic Prospects of Mulberry-Derived DNJ: A Review
Tejaswini A S, Kaveri Aramani, Veenita M K, Nikita Kankanawadi, Gagana Sindhu S, Basanagouda Jekinakatti
Journal of Advances in Biology & Biotechnology · pp. 292–308 · Published 30 Jul 2025
10.9734/jabb/2025/v28i82706Abstract
Deoxynojirimycin (DNJ) is a naturally occurring iminosugar primarily found in mulberry (Morus spp.) leaves and is known for its potent α-glucosidase inhibitory activity. Due to this property, DNJ plays a significant role in regulating blood glucose levels, making it a promising natural compound for the management of type 2 diabetes. Beyond its antidiabetic effects, DNJ exhibits potential in combating obesity and improving lipid metabolism. It also shows antiviral, antimicrobial, and hepatoprotective activities, expanding its therapeutic relevance. The extraction and purification of DNJ from mulberry have been optimized to enhance its yield and bioavailability. Overall, DNJ from mulberry presents a valuable bioactive compound with diverse applications in pharmaceuticals and functional foods.
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