Recent Developments on Novel Heterocyclic Compounds Thiadiazoles and Heterocyclic Compounds for COVID-19 Targets in Drug Discovery
B. Madhavi, G. Veera Raghava Sharma
Journal of Pharmaceutical Research International · pp. 681–697 · Published 30 Dec 2021
10.9734/jpri/2021/v33i64B36210Abstract
This article mainly reviews the recent developments in the synthesis of novel 1,3,4-Thiadiazoles and also recent development of drug molecules for the treatment of COVID-19. The Thiadiazole heterocycle and its derivatives are the most important class of compounds among various heterocyclic compounds due to their wide range of biological activities and pharmaceutical importance. Thiadiazolemoeity exists as a principal structural pharmacopore in the combination of drug categories such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antineoplastic, antitubercular agents. In this review article, we have attempted to show various synthetic procedures of thiadiazole derivatives along with their pharmacological activities and also the recent studies on Antiviral targets for the discovery of new drugs to combat Covid19 like viruses.
Cited by 2
Mohammad Auwal Sa’ad, Manickam Ravichandran, Lalitha Pattabhiraman · Results in Chemistry · 2024
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