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Research Article Open access CC BY 4.0

Elevated Levels of Lactate Dehydrogenase Predicts Poor Outcomes for Patients with COVID-19: A Review

Dheaa Shamikh Zageer

Asian Journal of Medicine and Health · pp. 139–158 · Published 13 Jan 2021

10.9734/ajmah/2020/v18i1130276

Abstract

In glucose (Glc) metabolism, lactate dehydrogenase (LDH) functions by changing pyruvate into lactate. Lactate dehydrogenase (LDH) release is induced viacell death, suggesting to disease caused by virus or pulmonary deterioration, such as inflammation of the lung triggered by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). A satisfactory evidence exists by binding elevated lactate dehydrogenase (LDH) levels to the development of coronavirus disease 2019 (COVID-19) complications.

lactate dehydrogenase LDH isozymes COVID-19 mortality.

References (76)

  1. 1 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [DOI]
  2. 2 Clinical Characteristics of Coronavirus Disease 2019 in China [DOI]
  3. 3 Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study [DOI]
  4. 4 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study [DOI]
  5. 5 Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China [DOI]
  6. 6 Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia [DOI]
  7. 7 Presumed Asymptomatic Carrier Transmission of COVID-19 [DOI]
  8. 8 A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia [DOI]
  9. 9 Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient [DOI]
  10. 10 The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease [DOI]
  11. 11 Clinical Characteristics of Refractory Coronavirus Disease 2019 in Wuhan, China [DOI]
  12. 12 Hematologic parameters in patients with COVID‐19 infection [DOI]
  13. 13 Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy [DOI]
  14. 14 Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS‐CoV‐2 [DOI]
  15. 15 Comprehensive review on lactate metabolism in human health [DOI]
  16. 16 C‐reactive protein correlates with computed tomographic findings and predicts severe COVID‐19 early [DOI]
  17. 17 The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor [DOI]
  18. 18 Clinical and High-Resolution CT Features of the COVID-19 Infection: Comparison of the Initial and Follow-up Changes [DOI]
  19. 19 Outcomes and Prognostic Factors in 267 Patients with Severe Acute Respiratory Syndrome in Hong Kong [DOI]
  20. 20 Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer [DOI]
  21. 21 Structural basis for altered activity of M‐ and H‐isozyme forms of human lactate dehydrogenase [DOI]
  22. 22 The Actual Role of LDH as Tumor Marker, Biochemical and Clinical Aspects [DOI]
  23. 23 CT manifestations of coronavirus disease-2019: A retrospective analysis of 73 cases by disease severity [DOI]
  24. 24 Lactate Dehydrogenases as Metabolic Links between Tumor and Stroma in the Tumor Microenvironment [DOI]
  25. 25 Death After Graft Loss: An Important Late Study Endpoint in Kidney Transplantation [DOI]
  26. 26 Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials [DOI]
  27. 27 Lactate dehydrogenase: a marker of diminished antitumor immunity [DOI]
  28. 28 The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients [DOI]
  29. 29 An enzymatic approach to lactate production in human skeletal muscle during exercise [DOI]
  30. 30 CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city [DOI]
  31. 31 Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer [DOI]
  32. 32 Hospitalized adult patients with 2009 influenza A(H1N1) in Beijing, China: risk factors for hospital mortality [DOI]
  33. 33 Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain [DOI]
  34. 34 Identification of human D lactate dehydrogenase deficiency [DOI]
  35. 35 Acute myocardial infarction in thrombotic microangiopathies—clinical characteristics, risk factors and outcome [DOI]
  36. 36 Lactate dehydrogenase predicts hypoxic ischaemic encephalopathy in newborn infants: a preliminary study [DOI]
  37. 37 Computational analyses of mammalian lactate dehydrogenases: Human, mouse, opossum and platypus LDHs [DOI]
  38. 38 Serum lactate dehydrogenase is predictive of persistent organ failure in acute pancreatitis [DOI]
  39. 39 Viral infection in community acquired pneumonia patients with fever: a prospective observational study [DOI]
  40. 40 Inhibition of lactate dehydrogenase A suppresses inflammatory response in RAW 264.7 macrophages [DOI]
  41. 41 Use of LDH and Autoimmune Side Effects to Predict Response to Ipilimumab Treatment [DOI]
  42. 42 l-Lactate Transport and Metabolism in Mitochondria of Hep G2 Cells—The Cori Cycle Revisited [DOI]
  43. 43 Prognostic Value of Lactate Dehydrogenase for Mid-Term Mortality in Acute Decompensated Heart Failure: A Comparison to Established Biomarkers and Brain Natriuretic Peptide [DOI]
  44. 44 LDH Concentration in Nasal-Wash Fluid as a Biochemical Predictor of Bronchiolitis Severity [DOI]
  45. 45 Human Lactate Dehydrogenase A Inhibitors: A Molecular Dynamics Investigation [DOI]
  46. 46 Serum Lactate Dehydrogenase in Interstitial Lung Disease [DOI]
  47. 47 Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach [DOI]
  48. 48 Physical therapy–induced rhabdomyolysis and acute kidney injury associated with reduced activity of muscle lactate dehydrogenase A [DOI]
  49. 49 An Imperative Need for Research on the Role of Environmental Factors in Transmission of Novel Coronavirus (COVID-19) [DOI]
  50. 50 Lactate dehydrogenase, a Risk Factor of Severe COVID-19 Patients: A Retrospective and Observational Study [DOI]
  51. 51 Home visits: a strategy to improve newborn survival - Authors' reply [DOI]
  52. 52 Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan [DOI]
  53. 53 COVID-19 pathophysiology: A review [DOI]
  54. 54 Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis [DOI]
  55. 55 Coronavirus disease 2019 (COVID-19): A literature review [DOI]
  56. 56 The role of biomarkers in diagnosis of COVID-19 – A systematic review [DOI]
  57. 57 Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis [DOI]
  58. 58 Analysis of SARS-CoV-2 vertical transmission during pregnancy [DOI]
  59. 59 COVID‐19 and the clinical hematology laboratory [DOI]
  60. 60 Routine blood tests as a potential diagnostic tool for COVID-19 [DOI]
  61. 61 Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients [DOI]
  62. 62 Laboratory findings of COVID-19: a systematic review and meta-analysis [DOI]
  63. 63 Decoding the evolution and transmissions of the novel pneumonia coronavirus (SARS-CoV-2 / HCoV-19) using whole genomic data [DOI]
  64. 64 Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19 [DOI]
  65. 65 Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis [DOI]
  66. 66 SARS‐CoV‐2: A comprehensive review from pathogenicity of the virus to clinical consequences [DOI]
  67. 67 Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control study [DOI]
  68. 68 Preventing COVID-19 in low- and middle-income countries [DOI]
  69. 69 Prognostic value of lactate dehydrogenase for in-hospital mortality in severe and critically ill patients with COVID-19 [DOI]
  70. 70 Clinical characteristics and prognosis of community-acquired pneumonia in autoimmune disease-induced immunocompromised host: A retrospective observational study [DOI]
  71. 71 Accurate Results in the Clinical Laboratory [DOI]
  72. 72 Biochemistry, Lactate Dehydrogenase (LDH)
  73. 73 Different Modes of Transmission and Containment Strategies for COVID-19 [DOI]
  74. 74 La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
  75. 75 Clinical findings of 35 cases with novel coronavirus pneumonia outside of Wuhan [DOI]
  76. 76 Prolonged viability of SARS-CoV-2 in fomites [DOI]

Cited by 1

PERBANDINGAN PARAMETER INFLAMASI DAN STATUS KOAGULASI PADA BERBAGAI DERAJAT BERAT COVID-19 DI SILOAM KEBON JERUK

Erick Makarau, Velma Herwanto · PREPOTIF : Jurnal Kesehatan Masyarakat · 2022

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