Hematological Profile of Adult Haemoglobin SS and SC Sickle Cell Patients in Stationary Phase: Evidences from National Teaching Hospital of Cotonou in Benin
A. Zohoun, T. Baglo-Agbodande, B. Houssou, R. MassI, E. Kassehin, G. G. Orou Guiwa, J. Dèhoumon, J. Mehou, L. Anani, A. Vovor, D. Kinde-Gazard
International Blood Research & Reviews · pp. 70–76 · Published 28 Aug 2023
10.9734/ibrr/2023/v14i4319Abstract
Background and Objective: Sickle cell disease is a major public health problem. The aim of this study was to determine the hematological parameters in the inter-critical period of adult sickle cell patients at the National Teaching Hospital CNHU-HKM of Cotonou. Materials and Methods: This is a descriptive study with analytical aims carried out from July 2021 to December 2021 in the hematology department of the National Teaching Hospital CNHU-HKM of Cotonou. An hemogram was performed using Sysmex XT 4000i on a total of 181 sickle cell patients including 119 Hb SS and 62 Hb SC. Data were analyzed using R software. Results: Patients studied had a mean age of 32 ± 13 years. The mean of hemoglobin level was 7.7 ± 1.9 g/dL in Hb SS patients versus 11.27 ± 1.79 g/dL in Hb SC patients (p = 0.001). The mean leukocyte count was 13.2 ± 4.4 G/L in Hb SS patients versus 7.3 ± 3 G/L in Hb SC patients (p = 0.003); the mean neutrophil count was 6.93 ± 3.24 G/L in Hb SS patients versus 3.96 ± 1.72 G/L in Hb SC patients (p = 0.001). Platelet counts averaged 426 ± 213 G/L in Hb SS patients versus 223 ± 103 G/L in Hb SC patients (p = 0.001). Conclusion: This study revealed a higher mean hemoglobin level, mean leukocyte count and mean platelet count in Hb SS patients compared to Hb SC patients in the stationary phase.
References (4)
- 1 Thrombin generation and cell‐dependent hypercoagulability in sickle cell disease [DOI]
- 2 Haematological values in sickle cell anaemia in steady state and during vaso-occlusive crisis in Benin City, Nigeria
- 3 Sickle cell disease: Hemostatic and inflammatory changes, and their interrelation [DOI]
- 4 Clinical and molecular characteristics of sickle cell anemia in the northeast of Brazil [DOI]
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