Anti-Hyperlipidemic Effect of Methanol Seed Kernel Extract of Mangifera indica on Wistar Rat Model

Abstract

The aim of this study was to evaluate the anti-hyperlipidemic effect of methanol Mangifera indica seed kernel extract on hyperlipidemic Wistar rats. Mango seed kernels were dried at room temperature before being ground into fine powder. 500 g of mango seed kernel powder was soaked in 500 mL of 98 % methanol and shaken intermittently for 72 h, after which the extract was concentrated. Twenty five adult male wistar rats were divided into five groups of five rats each. Group I: was administered 2 ml of distilled water. Groups II-V were induced hyperlipidemia. However, while Group II was not treated with the extract (negative control), Groups III and IV were treated with 150 and 350 mg/kg body weight of mango seed kernel extract (MSKE) and Group V was administered the standard drug (atorvastatin). Treatment lasted for 21 days, after which rats were sacrificed and blood sample was collected and subsequently analyzed via standard procedures. Hyperlipidemia was characterized by increased levels of total cholesterol and Low Density Lipoprotein (LDL). Oral administration of MSKE significantly (P<0.05) reduced the aforementioned indices to levels which though were significantly (P<0.05) higher than that reported for the normal control group. On the other hand, it was observed that that the levels of high density lipoprotein (HDL) and triacylglyceride (TG) in the negative control (Group II) were significantly (P<0.05) low but increased following oral administration of extract in a dose dependent manner. It was also observed that MSKE of M. indica reduced the body weight of hyperlipidemic rats. In conclusion, it can be deduced from this study that MSKE has the potential to address hyperlipidemia