Anti-Hyperglycemic Activity of Solvents Extract of Khaya senegalensis Stem Bark in Alloxan Induced Diabetic Rats

Abstract

Introduction: Diabetes mellitus is among the major global public health problems and its prevalence is currently increasing at an alarming rate. According to the International Diabetes Federation, about 366 million people are living with diabetes and this figure is projected to increase to 552 million by the year 2030. Aim: To investigate the effect of the Aqueous-methanol stem bark extract of Khaya senegalensis and its solvents (hexane, chloroform and ethyl acetate) extracts on alloxan induced diabetic rats. Methodology: A total of forty two rats were used and were grouped into seven groups of six rats each. Group I served as normal control, group II served as diabetic control, Group III rats were diabetic with alloxan and administered with standard drug (Chlorpropamide, 100 mg/kg) while Groups IV, V, VI and VII were diabetic and administered with crude extract, hexane, chloroform  and ethyl acetate extract respectively at a dose of 250 mg/kg for two weeks. Results: The research found that the ethyl acetate extract showed the highest potency with a significant (p<0.05) decrease in blood glucose level when compared to diabetic control after three days of extract administration, it was followed by the crude extract which also shows activity at day three. Chloroform and hexane extracts showed a marked anti-hyperglycemic activity only after twelve days of extracts administration. Conclusion: The present study demonstrated that the ethyl acetate extract possesses the highest hypoglycemic activity.