Glutathione-S-Transferase Pi and Malondialdehyde in Alcoholic Patients Attending Smhrc and Avbrh Hospital

Abstract

Introduction: Alcohol abuse is a global health problem. The liver maintains high muscle damage by over drinking because it is a major source of ethanol metabolism. Among substance abusers, about 35 % develop advanced liver disease because the number of viral mutations increases, slows down, or inhibits the progression of liver disease. Glutathione-S-transferase is a family of Phase II enzyme-releasing toxins that cause the synthesis of glutathione in a variety of chronic and external electrophilic types. GSTs are divided into two very different family members: family members bound by microsomal membrane and cytosolic. Aim: To study the Glutathione S Transferase π and Malondialdehyde in Alcoholic Patients. Materials and Methods: Present study comprises 100 Subjects were included in the study and distributed in two groups. Patients from group one was alcoholic patients, enrolled from medicine ward and 50 non-alcoholic healthy individuals from group two were from non-alcoholic population as well as medicine ward. Results: Rise of GGT, AST and ALT in Alcoholic patients (54.54 ± 3.72, 19.21 ± 0.68 and 24.32 ± 1.27 respectively) as compare to healthy individuals (24.40 ± 3.16, 10.36±0.35 and 17.06±0.84 respectively). The level of GST-π was decreased in alcoholic patients (62.44±26.30) as compare to control group (83.26±32.71). Similarly, the level of MDA was raised in alcoholic patients (5.36 ± 0.51) as compare to healthy individuals (4.73 ± 0.21). Conclusion: Present study suggests that it would be vital to contain SGOT, SGPT, GGT, MDA and GST-π calculation in the prognostic assessment of alcoholic patients.