Effects of Silymarin on Oxidative Stress Markers in Rats Treated with Magnesium Oxide Nanoparticles
Masoud Negahdary, Mahnaz Bezhgi, Marziyeh Ajdary
Annual Research & Review in Biology · pp. 254–261 · Published 6 Oct 2014
10.9734/ARRB/2015/10949Abstract
This study investigated the protective and anti-oxidative effects of silymarin on rats treated with MgO NPs. Number of 32 male wistar rats were used in this experiment, assigned to four groups; one, the control group and the three others were treatment groups. The treated groups inclusive of a group receiving 400 ppm Mg NPs, a group received 200 mg/kg silymarin, and a group received silymarin and that dose of Mg NPs. All groups received the treatment peritoneally as long as four weeks uninterruptedly. Post-treatment tissue level of malondialdehyde as well as the activities of catalase, glutathione peroxidase and superoxide dismutase were measured in the liver. The data were analyzed by implementation of one-way ANOVA and Bonferroni tests. In animals treated with MgO NPs, MDA level significantly increased (P=0.000), while a significant decrease was observed in GPX (P=0.000), SOD (P=0.001), and CAT (P=0.008) activities. However, silymarin prevented the effect of them in the group receiving silymarin and MgO NPs significantly and caused an increase in GPX, SOD and CAT activities as well as a decrease in MDA level (P<0.05). As, nanoparticles have harmful effects on the body raised from the generation of reactive oxygen species, this study showed that silymarin, with its antioxidant properties, may decrease free radicals produced by MgO NPs.
References (23)
- 1 [13] Catalase in vitro [DOI]
- 2 Selenium: Biochemical Role as a Component of Glutathione Peroxidase [DOI]
- 3 Renal clearance of quantum dots [DOI]
- 4 Role of oxidative stress in atherosclerosis [DOI]
- 5 Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stress [DOI]
- 6 Toxicologic effects of gold nanoparticles in vivo by different administration routes [DOI]
- 7 Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain [DOI]
- 8 A review of TiO2 nanoparticles
- 9 Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice [DOI]
- 10 Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles [DOI]
- 11 Oxidative stress and toxicity of gold nanoparticles in Mytilus edulis [DOI]
- 12 Herbal products for liver diseases: A therapeutic challenge for the new millennium [DOI]
- 13 Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas [DOI]
- 14 Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury [DOI]
- 15 Silver nanoparticles: cytotoxic, apoptotic, and necrotic effects on MCF-7 cells [DOI]
- 16 Silymarin, a natural antioxidant, protects cerebral cortex against manganese-induced neurotoxicity in adult rats [DOI]
- 17 Effect of gold nanoparticles on glutathione and malondialdehyde levels in liver, lung and heart of rats [DOI]
- 18 Changes in concentrations of tissue free radical marker and serum creatine kinase during the post-exercise period in rats [DOI]
- 19 Effect of 67Zn-Nanoparticles on Leukemic Cells and Normal Lymphocytes [DOI]
- 20 Effects of parsley (Petroselinum crispum) on the liver of diabetic rats: a morphological and biochemical study [DOI]
- 21 Direct Electron Transfer of Hemoglobin on Manganese III Oxide-Ag Nanofibers Modified Glassy Carbon Electrode [DOI]
- 22 Influence of Nano-Silver on Graffian Follicles via Intraperitoneal Injection in Rats
- 23 The use of naturopathic remedies for chronic liver disease.
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