Fleurya Aestuans Leaves and Tetrahydroxyflavone Mitigate Lead Induced Testicular Toxicity in Wistar Rats
Charles C. Nwafor, Ifedi I. Charles, Ekikereabasi P. Inyang, Solomon M. Uvoh, Okache B. Ogwihi, Alagha B. Ebiyemzi
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 35–47 · Published 20 Dec 2021
10.9734/jamps/2021/v23i1030265Abstract
The effects of Fleurya aestuans leaves and tetrahydroxyflavone on the reproductive functions of lead acetate induced testicular toxicity in Wistar rats was investigated in this study. The study animals were divided into control group (A) and toxicity-induced groups (B, C, D, E, F, and G). To determine all particulate parameters under inquiry, the study used established procedures. Histological and tissue biochemical studies were performed on the testes and caudal epididymis. The most active compound in the extract was found to be tetrahydroxyflavone, and treatment of the extract resulted in a significant (P<0.05) improvements in male mating behaviors, conceptive hormones, sperm parameters, and testicular biochemical parameters. The frequency of mount, intromission and ejaculation rose significantly (P<0.05), but the latencies of mount, intromission, and ejaculation, decreased. Similarly, the treatment of the extract with tetrahydroxyflavone reversed the harmful effects of lead acetic acid on various organ systems in the research animals, such as the epididymis and testes. As a result, the study recommends that Fleurya aestuans leaves be used to treat reproductive problems. The dose in human being experiment may be beneficial to patients with reproductive problems.
References (4)
- 1 World Health Organization reference values for human semen characteristics*‡ [DOI]
- 2 Effect of Oxidative Stress on Male Reproduction [DOI]
- 3 Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia [DOI]
- 4 Ethnobotanical knowledge of medicinal plants used in the treatment of male infertility in southern Benin [DOI]
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