Skip to content
I

Ifedi I. Charles

Publications (9)

Biochemical Modulation of Streptozotocin Neurotoxicity by Cinnamonum Verum Bark Extract in Wistar Rats

Ifedi I. Charles, Nwafor C. Charles, Ojimba M. Immaculata, Okeke J. Chioma & Jacob A. Akpan · European Journal of Medicinal Plants · 2025

This study investigates the effects of Cinnamomum verum bark extract on Streptozotocin (STZ) induced neurotoxicity in Wistar rats. Twenty five (25) Male Wistar rats weighing between 93.4 -107.6g were divided into five groups: Group A: Control, Group B 65mg/kg STZ, Group C 65mg/kg...

Open access Research Article 10.9734/ejmp/2025/v36i21250

Ginkgo biloba and Curcuma longa Root’s Synergistic Potency on Neurobehaviour of Streptozotocin-Induced Neurodegenerative Disorders

Ifedi I. Charles, Nwafor C. Charles, Ifedi B. Ochanya, Igwedibia C. Paul & Ojimba M. Immaculata · Annual Research & Review in Biology · 2025

Neurodegenerative conditions like anxiety, depression, and Alzheimer's disease can result from prolonged exposure to stress. Herbal supplements like Ginkgo biloba and Curcuma longa (turmeric) are being investigated as a result of the search for natural neuroprotective agents. In...

Open access Research Article 10.9734/arrb/2025/v40i32208

Cannabis sativa Boosts Brain Functions and Ameliorate Anxiety, when used Sensibly and not Abusively

Ifedi I. Charles, Okoye O. Fidelis, Emeka Ugwuishi, Nwafor C. Charles, Ifedi O. Blessing & Okeke B. Chidimma · European Journal of Medicinal Plants · 2024

Cannabis sativa is an illegal substance with documented analgesic, antipyretic, anti-inflammatory, and anti-diarrheal properties. Numerous other cannabinoids found in cannabis have an impact on brain activity. So, the purpose of this study was to examine how cannabis sativa extra...

Open access Research Article 10.9734/ejmp/2024/v35i21186

The Effects of Mkpuru Mmiri Consumption on Cognitive Performance and Brain Histology in an Animal Study

Ifedi I. Charles, Nwafor C. Charles, Ihezuruoha C. Salome, Ovie F. O, Ifedi O. Blessing & Igwedibia C. Paul · Journal of Pharmaceutical Research International · 2024

Mkpuru mmiri, popularly known as ice or methamphetamine (METH) is one of the illegal substances that young people in Nigeria abuse most frequently. The purpose of the study is to determine how methamphetamine affects the cognitive-motor behavior of Wistar rats. In the study, twen...

Open access Research Article 10.9734/jpri/2024/v36i67521

Hormonal and Morphological Effects of Averrhoea carambola Fruit Extract on Female Reproduction

Ifedi I. Charles, Emeka Ugwuishi, Ifedi O. Blessing, Nwafor C. Charles, Okeke C. Jennifer, Okoye O. Fidelis & Ihezuruoha S. Chinyere · Journal of Advances in Medicine and Medical Research · 2023

Medical herbs are dazzling resources that influences female fertility. The effect of Averrhoa carambola ethanolic fruit extract on gonadal function and structure in female Wistar rats was investigated in the study. 15 Wistar rats weighing 100 to 143g were divided into three group...

Open access Research Article 10.9734/jammr/2023/v35i195164

Jack Fruit: An Estimation of Hunteria Umbellata Fruit Extract against Formalin Induced Nociception

Ifedi I. Charles, Ifedi O. Blessing, Nwafor C. Charles, Igwedibia C. Paul & Okoye O. Fidelis · Journal of Advances in Medicine and Medical Research · 2023

The purpose of the study is to ascertain the impact of ethanolic fruit extract from Hunteria umbellata on formalin-induced nociception in Wistar rats. Six sets of thirty Wistar rats, weighing 110.7 to 169.4 g each, were employed for the investigation. Group 1 functioned as the co...

Open access Research Article 10.9734/jammr/2023/v35i115025

Fleurya Aestuans Leaves and Tetrahydroxyflavone Mitigate Lead Induced Testicular Toxicity in Wistar Rats

Charles C. Nwafor, Ifedi I. Charles, Ekikereabasi P. Inyang, Solomon M. Uvoh, Okache B. Ogwihi & Alagha B. Ebiyemzi · Journal of Advances in Medical and Pharmaceutical Sciences · 2021

The effects of Fleurya aestuans leaves and tetrahydroxyflavone on the reproductive functions of lead acetate induced testicular toxicity in Wistar rats was investigated in this study. The study animals were divided into control group (A) and toxicity-induced groups (B, C, D, E, F...

Open access Research Article 10.9734/jamps/2021/v23i1030265

Metformin and Caffeine’s Influence on Lipid Profile Indices of Streptozotocin-Induced Dyslipidemia in an Animal Model

Okafor K. Oluchi, Nwafor C. Charles, Ifedi I. Charles, Ovie F. O, Agbor Joseph & Nwachukwu C. Daneil · Journal of Pharmaceutical Research International · 2024

Dyslipidemia has been linked to insulin resistance and hyperglycemia. Hyperglycemia, which is the outcome of either insufficient insulin production or insensitivity to insulin, is the hallmark of diabetes mellitus (DM). In this study, thirty-six (36) male Wistar rats with diabete...

Open access Research Article 10.9734/jpri/2024/v36i107586

Technology-assisted Neurobehavioral and Histomorphometric Assessment of Chronic Lead and Cadmium Exposure in an Animal Study

Ndubuisi F. Nwodo, Charles C. Nwafor, Okafor K. Oluchi, Ifedi I. Charles, Jacob A. Akpan & Felix O. Ogbo · Biotechnology Journal International · 2026

Backgrounds: Heavy metals like lead (Pb) and cadmium (Cd) are toxic environmental pollutants that cause serious health effects, particularly neurotoxicity, organ damage, and carcinogenic risks. Their combined exposure can enhance toxicity through synergistic interactions, increas...

Open access Research Article 10.9734/bji/2026/v30i2867