Evaluation of Antidiabetic Potential of Ethanolic Extracts of Cissus quadrangularis and Cinnamomum tamala - An in vitro Study

Abstract

Background: Diabetes is a rapidly growing metabolic disorder of the present generation. Uncontrolled diabetes leads to various complications which in turn affects the vascular system, neuropathy,and more. Medicinal plants are always a good source of drug equivalent  currently present. Antidiabetic drugs lead to a large amount of side effects. A comparative study was made between Cissus quadrangularis and Cinnamomum tamala for its antidiabetic potential. Aim: To evaluate the antioxidant and antidiabetic potential of ethanolic extract of Cissus quadrangularis and Cinnamomum tamala and to compare its efficacy. Materials and Methods: Ethanolic extracts of Cissus quadrangularis and Cinnamomum tamala were tested for its phytoconstituents, antioxidant and antidiabetic potential.The data were analyzed statistically by one-way analysis of variance (ANOVA) followed by Duncan’s multiple range test and it was used to see the statistical significance among the groups. The results with the p<0.05 level were considered to be statistically significant. Results: Phytochemical screening  showed a strong  presence of flavonoids and terpenoids in both the plant extract. Results showed that plant extract had antidiabetic and antioxidant activity.  Among them Cissus quadrangularis exhibited significantly more antidiabetic and antioxidant activity. Conclusion: The ethanolic extract of Cissus and Cinnamomum tamala exhibits potent antidiabetic and antioxidant properties. With further invivo and invitro studies the plant extract can be formulated into a potent antidiabetic drug.