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Research Article Open access CC BY 4.0

Dyslipidemia Protective Effect of Resistant Starch-Based Dough Meals on Diabetes-Induced Rats

Aderonke Adenike Oladebeye, Tayo Nathaniel Fagbemi, Oluwole Steve Ijarotimi

European Journal of Nutrition & Food Safety · pp. 141–152 · Published 28 Nov 2023

10.9734/ejnfs/2023/v15i111361

Abstract

Aim: The adoption of functional foods as healthy diet therapy for the management of metabolic disorders such as diabetes is in vogue in the present world where many are no longer consuming carbohydrate or starchy foods. This study investigated the effect of resistant starch-based dough meals on dyslipidemia in rats with streptozotocin (STZ)-induced diabetes. Place and Duration: Functional Foods Laboratory and Animal House of Department of Biochemistry, Federal University of Technology, Akure, from July 2022 to February 2023. Methodology: Flour samples were prepared by dispersing the flour into boiling water and turning and being allowed to cook for 15 min to obtain dough meals:  PLD – (100% Plantain flour), used as a control sample; PLPRD – plantain flour: pigeon pea flour: rice bran flour (73.08:15.15:11.76); PSPRD – native plantain starch: pigeon pea flour: rice bran flour (73.08:15.15:11.76); AP1SPRD – acetylated plantain starch: pigeon pea flour: rice bran flour (73.08:15.15:11.76); AP2SPRD – acetylated plantain starch: pigeon pea flour: rice bran flour (70.67:18.15:11.18). The weight gained, food intake, haematological parameters, fasting blood glucose and lipid profile of the resistant starch-based dough meal were compared with the commercial flour product, CRD (100% Cerolina flour: wheat and soybean) and the DM (untreated high-fat diet–STZ-induced diabetic rats) and NC (Normal control rats). Results: The weight gained and food intake ranged from 50.98±0.53 g to 180.12±1.07 g in NC and 33.98±1.64 g to 140.87±1.80 g in DM. The feed conversion ratio to the feed efficiency ratio was 0.28:0.25 and 4.15:3.53 in NC and DM respectively, which attributed to the food product to weight loss. The values of the haematological parameters (PCV, RBC, HB, MCV, MCH and MCHC) confirmed that the experimental rats had no trace of infection due to the generation of antibodies by WBC and differential counts (neutrophils, eosinophils, basophils, monocytes and lymphocytes). Rats fed with DM+AP1SPRD showed a decrease in low-density lipoprotein cholesterol (LDL-C), total cholesterol and triglyceride, and an increase in high-density lipoprotein cholesterol (HLDL-C). Conclusion: A resistant starch-based dough meal was significant for the production of short-chain fatty acids with lots of benefits on health. The intervention of resistant starch-based dough meals, AP1SPRD and AP2SPRD used in this study, almost normalized metabolic profiles in the experimental rats, similar to the control group by reducing the total cholesterol, total triglycerides and LDL-C while increasing HDL-C.

Dough meal resistant starch dyslipidemia diabetes induced rats

References (41)

  1. 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
  2. 2 Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants [DOI]
  3. 3 Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice [DOI]
  4. 4 Resistant Starch–A Review [DOI]
  5. 5 Resistant starch as functional ingredient: A review [DOI]
  6. 6 Health properties of resistant starch [DOI]
  7. 7 Dietary Fiber, Atherosclerosis, and Cardiovascular Disease [DOI]
  8. 8 Position of the American Dietetic Association: Functional Foods [DOI]
  9. 9 Amaranth oil application for coronary heart disease and hypertension. [DOI]
  10. 10 Dyslipidemia and cardiovascular disease risk among the MASHAD study population [DOI]
  11. 11 Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters [DOI]
  12. 12 Effects of Resistant Starch, A Non‐digestible Fermentable Fiber, on Reducing Body Fat [DOI]
  13. 13 Cereal complex carbohydrates and their contribution to human health [DOI]
  14. 14 Position of the American Dietetic Association: Functional Foods [DOI]
  15. 15 Structure, morphology and functionality of acetylated and oxidised barley starches [DOI]
  16. 16 Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging [DOI]
  17. 17 Dyslipidemia and the Risk of Developing Hypertension in a Working‐Age Male Population [DOI]
  18. 18 Thermal properties and resistant starch content of green banana flour (Musa cavendishii) produced at different drying conditions [DOI]
  19. 19 Resistant starch: A review of analytical protocols for determining resistant starch and of factors affecting the resistant starch content of foods [DOI]
  20. 20 Class 2 Resistant Starches Lower Plasma and Liver Lipids and Improve Mineral Retention in Rats [DOI]
  21. 21 Lipid Metabolism, Disorders and Therapeutic Drugs - Review [DOI]
  22. 22 Effects of stabilized rice bran, its soluble and fiber fractions on blood glucose levels and serum lipid parameters in humans with diabetes mellitus Types I and II [DOI]
  23. 23 Acetylation of rice starch in an aqueous medium for use in food [DOI]
  24. 24 HDL-C: Role as a risk modifier [DOI]
  25. 25 Resistant Starch and Energy Balance: Impact on Weight Loss and Maintenance [DOI]
  26. 26 Role of Dietary Fiber and Short-Chain Fatty Acids in the Colon [DOI]
  27. 27 Lipid Disorders in Diabetes Mellitus and Current Management [DOI]
  28. 28 Novel High-Fat Diet Formulation and Streptozotocin Treatment for Induction of Prediabetes and Type 2 Diabetes in Rats [DOI]
  29. 29 Sex-specific reference intervals for Wistar albino rats: hematology and clinical biochemistry [DOI]
  30. 30 Gaseous Ozonation of Pigeon Pea, Lima Bean, and Jack Bean Starches: Functional, Thermal, and Molecular Properties [DOI]
  31. 31 Plantain based dough meal: nutritional property, antioxidant activity and dyslipidemia ameliorating potential in high-fat induced rats [DOI]
  32. 32 Plantain‐based dough meal: Nutritional property, antioxidant activity and dyslipidemia ameliorating potential in high‐fat‐induced rats [DOI]
  33. 33 Biochemical Ameliorating Potential of Optimized Dough Meal from Plantain (Musa AAB), Soycake (Glycine max) and Rice bran (Oryza sativa) Flour Blends in Streptozotocin Induced Diabetic Rats [DOI]
  34. 34 Banana starch intervention ameliorates diabetes-induced mood disorders via modulation of the gut microbiota-brain axis in diabetic rats [DOI]
  35. 35 Interpretation of Full Blood Count Parameters in Health and Disease [DOI]
  36. 36 Heat Moisture Treatment of High Amylose Cornstarch Increases Its Resistant Starch Content but Not Its Physiologic Effects in Rats [DOI]
  37. 37 Current trends and perspectives in nutrition and cancer prevention.
  38. 38 Composition and sensory properties of plantain cake [DOI]
  39. 39 Nutritional and Antioxidant Properties of Resistant Starch-Based Flour Blends from Unripe Plantain, Pigeon Pea and Rice-Bran [DOI]
  40. 40 In vitro antioxidants and haematological and nephroprotective effects of biscuits produced from three medicinal flour blends fed to high-fat diet/streptozotocin (STZ)-induced diabetic rats [DOI]
  41. 41 Physical and biochemical studies on excess weight-induced rats maintained on mixed spices-supplemented diet [DOI]

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