Assessment of Curacron Toxicity on Liver PUFAs Profile and Histology in a Major Carp, Cirrhinus mrigala

Abstract

The present finding, evaluated acute toxicity of curacron organophosphate pesticides on the freshwater edible fish Cirrhinus mrigala by assessing its LC50 values at intervals of 24, 48, 72, and 96 hours that is 0. 20 ml/L. Additionally, to observed the acute effects of curacron, sub-lethal concentration (1/10) 0.020 ml/L of calculated LC50 induced in different sets of aquariums, each contain six Cirrhinus mrigala against the control set to evaluated PUFA and alteration of liver histology after 7, 14, 21, and 28 days.  Sub lethal level of curacron, showed alterations in fish behavior like hyperactivity, erratic swimming, increased opercula movement surfacing, and cessation feeding, disturbances of normal physiological functions also were noted. In liver Omega-3 and Omega-6 fatty acid resulted progressive structural damage in liver, reduced lipid peroxidase, and changes in PUFA profiles after applying one way ANOVA test (p<0.05) against control set. Histology of liver revealed degradation of nuclei, cell swelling, cytoplasmic breakdown, hepatocytes, the development of vacuoles, expansion of sinusoidal spaces, alterations in the central vein, and deterioration in the sinusoid. These findings indicated that the released of pesticides had a substantial negative effect on aquatic life, decline in water purity and the ecosystem of water resources.