Rosuvastatin-Ca was prepared in solid dispersion as buccoadhesive tablets to increase its bioavailability and the release of the drug from its buccoadhesive formulae due to its poor aqueous solubility. The solid dispersions were prepared using β-cyclodextrin, polyethylene glycol...
Open access
Research Article10.9734/BJPR/2014/9257
Aim: In the present study, Sumatriptan succinate was formulated as oral elementary osmotic pump with a zero-order drug release profile. Methodology: The effect of different formulation variables i.e. different types of osmogens, concentrations of osmogen and concentration of coat...
Open access
Research Article10.9734/BJPR/2014/8666
Aims: To investigate the influence of appropriate culture medium by optimizing the cultural conditions affecting the growth and bioactive metabolite production by Streptomyces gulbargensis DAS 131 under submerged culture conditions in order to reduce the cost of fermentation proc...
Open access
Research Article10.9734/BJPR/2014/7085
Back Ground and Objectives: Despite the therapeutic benefits of cisplatin (CDDP), its use clinically is often limited due to dose-related nephrotoxicity. On the meanwhile, DPP 4 inhibitors could attenuate kidney injury, so in the present work, it was aimed to investigate the effe...
Open access
Research Article10.9734/BJPR/2014/9297
Background: Decaying stem juice of Musa acuminata × balbisiana is commonly used by local communities and traditional herbalist in Central Uganda in the management of cardiovascular conditions like hypertension. Aims: The study investigated the ionotropic and chronotropic effect o...
Open access
Research Article10.9734/BJPR/2014/6529
Chlorambucil (CLB) is an aromatic nitrogen mustard and an alkylating agent. It has been mainly used in the chemotherapy. A method for radiopharmaceutical preparation of [125I]-iodo-Chlorambucil a potential cancer therapeutic agent is described. The method is based on direct elect...
Open access
Research Article10.9734/BJPR/2014/10520
Background: A “near miss” or close call is a medication error that happened but did not result in injury or damage to the patient. These medication errors (MEs) are captured and corrected before affecting the patient either fortuitously or purposefully by designed system controls...
Open access
Research Article10.9734/BJPR/2014/8607
Aim: The aim of this study is to determine the effect of aqueous extract of Psidium guajava leaf on blood glucose level and liver enzymes of alloxan –induced diabetic rat. Study Design: The animals were grouped into six of 6 rats each. Groups A, B, C and E were induced diabetes b...
Open access
Research Article10.9734/BJPR/2014/7244
Aims: Adenium obesum is a known medicinal plant thereby creating the need for the evaluation of its toxicity and histopathological effects on the liver of female Wistar rats orally administered ethanol extract of the plant’s stem bark. Place and Duration of Study: Department of V...
Open access
Research Article10.9734/BJPR/2014/7667
Aim: The aim of this study was to evaluate the synergistic effect of low radiation dose with the chemotherapeutic drug in order to find possible way to lessen the harmful effects during chemo-radiotherapy. Study Design: Randomized controlled experiment. Place and Duration of Stud...
Open access
Research Article10.9734/BJPR/2014/8980