Renoprotective Effect of Sitagliptin ( Dipeptidyl Peptidase- 4 Inhibitor) aganist Cisplatin Induced Nephrotoxicity in Mice

Abstract

Back Ground and Objectives: Despite the therapeutic benefits of cisplatin (CDDP), its use clinically is often limited due to dose-related nephrotoxicity. On the meanwhile, DPP 4 inhibitors could attenuate kidney injury, so in the present work, it was aimed to investigate the effect of one of DPP 4 inhibitors (sitagliptin) on cisplatin induced nephrotoxicity in mice. Materials and Methods: 48 male balb-c mice were equally divided into 4 groups, control, sitagliptin group, cisplatin group and cisplatin plus sitagliptin group. The mice were sacrificed at 72h after cisplatin injection. Blood urea nitrogen (BUN) & serum creatinine, renal tissue of antioxidant enzymes, lipid peroxidation, TNF-alpha (TNF-α) were measured as well as histopathological scoring of renal injury. Results: The results demonstrated that sitagliptin significantly ameliorated the nephrotoxic effect of cisplatin with increased activity of antioxidant enzymes, improved kidney function, renal histopathological scoring and decreased tissue level of TNF-α. Conclusions: It can be concluded that sitagliptin may play a protective effect against cisplatin induced acute nephrotoxicity via antioxidant and anti-inflammatory pathway.