Researchers have focused on time-dependent infectivity, exploring specimens from patients in hospitals and cell lines in in vitro studies; less attention is given to time regimes before infection and early viral load peaks. The theoretical study aims to address the period of time...
Open access
Research Article10.9734/ijpr/2025/v14i6416
Kinetic and thermodynamic parameters for viral replication and depletion were given less attention in the literature. The activation energies for viral replication (e.g., 135—167 kJ/mol), clearance (119.1—137.3 kJ/mol), and cell death (e.g., 119.5—137.8 kJ/mol) were lower earlier...
Open access
Research Article10.9734/ijpr/2025/v14i3366
Much attention has been paid to the genetic composition and molecular biology of viral particles, infection, and micro-anatomical impacts that culminate in fatalities; vaccines have been in continuous development and production; less attention is paid to the fundamental issues of...
Open access
Research Article10.9734/ijpr/2025/v14i3365
The use of the reduced mass concept as opposed to the rest mass seems to give conflicting results. The objectives were to derive variants of the equation of the Rydberg constant (R∞), fine structure constant, and wave number that relate with the Rydberg constant. The derived R∞ e...
Open access
Research Article10.9734/ajr2p/2025/v9i1180
Backed by kinetic schemes, attempts have been made to derive equations for the calculation of all zero-order first-order rate constants (ZOFORC) for the activation of the enzyme-substrate (ES) complex and its deactivation. The values of ZOFORC, including the kind for the dissocia...
Open access
Research Article10.9734/ajbgmb/2023/v15i1327
Concern has been expressed against the new theories, Heisenberg uncertainty principle (HUP) and Schrödinger wave/quantum mechanics (SE) that are purported to have replaced Bohr’s theory and equation. The research was undertaken with the following objectives: 1) to review concerns...
Open access
Research Article10.9734/ajarr/2022/v16i12458
Background: Targeting of macromolecules by means of translational diffusion for therapeutic reason is generally of interest. But translational velocity that enables directional delivery of any molecule on target is given less attention. Objectives: The objectives of this research...
Open access
Research Article10.9734/ajrb/2019/v5i330089
Background: There seems to be a mathematical or a conceptual error in an equation whose substitution into other equations for the determination of an apparent hydrated molar volume (V1) of a cosolute leads to an incorrect answer. Objectives: The objectives are 1) To show theoreti...
Open access
Research Article10.9734/ajrb/2019/v5i230087
Background: There may be dry enzymes, but water remains indispensable for the catalytic action of enzymes. There is not as much interest in how the presence of a drug such as aspirin and a psychoactive compound such as ethanol may affect the water-mediated role of the enzyme. Obj...
Open access
Research Article10.9734/ajrb/2019/v5i230085
Background: There has been different interpretation of kosmotropes and chaotropes without concern for the physicochemical characteristics of the macromolecule and for the link between Hofmeister phenomena with solution structure. The objectives of this research are: 1) To investi...
Open access
Research Article10.9734/ajrb/2019/v4i330068
Background: Researchers who have shown interest in the consequence of introducing dry biomolecules or a solution of it into cosolvents generally known as osmolyte, have applied many models for the elucidation of the scientific basis of the results obtained. The Kirkwood and Buff...
Open access
Research Article10.9734/ajopacs/2019/v7i130086
Introduction: Researchers adopt different duration of the assay for a given concentration of the enzyme using different substrate concentration ranges. The kinetic parameters (KP) may not be the same for the different duration of the assay. Therefore, it is imperative to determin...
Open access
Research Article10.9734/AJOPACS/2018/44468
Objectives: The objectives of this research were to show that fine structure constant (a) is an intrinsic property of any matter (element) and 2) to relate it to other physical property of elements such as Bohr’s radius of any element and effective nuclear charge. Methods: The me...
Open access
Research Article10.9734/AJOPACS/2017/36931
Objectives: The objectives of this research were mainly to determine the rate of amylolysis of glycosidic bond and to formulate a dimensionally consistent quadratic equation for the determination of the changes in the concentration of substrate, molar concentration of product and...
Open access
Research Article10.9734/JALSI/2017/36862
Aims: The aims of this investigation were to determine: 1) the distribution of time and time-dependent events in a catalytic cycle, 2) maximum and minimum (average) interparticle distance between interacting molecules, 3) quantify the entropic term, and 4) elucidate the implicati...
Open access
Research Article10.9734/IJBCRR/2016/31203
Aims: The aims were: i) To ascertain the applicability of a model for the determination of the effect of calcium depletion, to the effect of the presence of the calcium chloride, ii) Quantify the thermodynamic activation parameters for unfolding of the enzyme with increasing temp...
Open access
Research Article10.9734/AIR/2016/27650
Aims: To: i) show that unfolding and folding of an enzyme can be investigated or interpreted using different aspects of the same model ii) determine the folding rate constant; iii) determine the equilibrium constant for folding; iv) determine activation parameters for unfolding a...
Open access
Research Article10.9734/AIR/2016/26332
Aims: The objectives of the in vitro study were to examine the applicability of thermodynamic models for the interaction of reaction mixture components to enzyme catalyzed reaction, and to determine the effect of co – solutes on the velocity of hydrolysis of a substrate with alph...
Open access
Research Article10.9734/AIR/2016/24269
Aims: Verify a derived kinetic parameter dependent model for the determination of Gibbs free energy of activation and consequently rate constant and to show that despite criticism against the process, Lineweaver Burk plot and the rate constant, both process and term remain indisp...
Open access
Research Article10.9734/JSRR/2016/24857
Aims: The specific aims of the research were i) to investigate the effects of extra “load” of calcium chloride at different temperatures and ethanol on the specific activity of porcine alpha amylase (PPA), ii) characterize the effect of extra calcium chloride in terms of thermody...
Open access
Research Article10.9734/IJBCRR/2016/24761
Aim: The objective of the research was to verify a simple mathematical model for the determination of mass concentration and the molar mass of an enzyme in any solution using standard solution of Aspergillus oryzea alpha amylase and the action of A. oryzea alpha amylase on heat t...
Open access
Research Article10.9734/JSRR/2016/24321