Background: Previous research has shown that the intrinsic reverse (backward) and forward rate constants are larger than the effective or apparent rate constants for the formation and dissociation of an enzyme-substrate complex (ES). It is speculated that such intrinsic rate cons...
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Research Article10.9734/ajocs/2022/v12i3219
Background: Atomic physics and nuclear matter physics are often exclusively studied. However, atomic properties are a direct function of nuclear properties. Establishing a mathematical relationship between nuclear and atomic properties could serve the interest of nuclear and atom...
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Research Article10.9734/ajr2p/2022/v6i3117
Objectives: This research was undertaken to determine the non–equilibrium binding energy by calculation after substituting experimental data into derived equations, present its role distinct from energy associated with activated enzyme–substrate (ES) complex and ultimately elucid...
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Research Article10.9734/ajocs/2020/v8i319044
Background: The literature contains numerous values of nucleon charge radii with greater interest in proton. The mean square negative radii are reported for the neutron, the scientific relevance notwithstanding. Only in very few instances was the mass radius of the nucleon invest...
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Research Article10.9734/ajr2p/2020/v3i430125
Background: There had always been a spirited effort in understanding the transport of air or molecular oxygen plus other gases from alveolar air space into the pulmonary capillaries and from the latter back into the former using mathematical models; the determination of the numbe...
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Research Article10.9734/ajob/2020/v10i130098
Background: There is a need for equations with which to calculate the intrinsic rate constants that can further characterise enzyme catalysed reactions despite what seems to be conventional differences in methodology in the literature. Methods: Theoretical, experimental (Bernfeld...
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Research Article10.9734/ajocs/2020/v8i219037
Background: The impression given in the literature was that the net interaction potential energy, V is the difference between Coulombic-Coulombic and total weaker interaction energies. It is proposed however, that in aqueous solution all particles with full formal charges and par...
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Research Article10.9734/ajacr/2020/v5i130123
Background: The equation of the difference between reverse and forward Gibbs free energy of activation (ΔΔGES#) reflects Michaelis-Menten constant (KM) in both directions; this may not be applicable to all enzymes even if the reverse reaction is speculatively Michaelian. Arrheniu...
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Research Article10.9734/ajopacs/2019/v7i430103
Background: There is no much interest in the determination of total enzyme-substrate complex concentration ([ES]T) which includes undissociated ES that is unaccounted for unlike the usual ES destined for transformation into free enzyme and product or substrate. The reason is spec...
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Research Article10.9734/ajrb/2019/v5i430105
Background: There has been recent shift from the core issue of Michaelian kinetics to issues regarding various kinds of quasi-steady-state assumptions. Derivable equations with which to determine reverse rate constant for the dissociation of enzyme-substrate complex (ES) is given...
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Research Article10.9734/ajopacs/2019/v7i430101
Background: It is not unusual to observe calculated “total” free enzyme ([E]) in enzyme catalysed reaction, but this should include total enzyme-substrate complex ([EST]) which accounts for sequestration. Objectives: 1) To show indirectly that the velocities of catalytic action c...
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Research Article10.9734/ajrb/2019/v5i430098
Objectives: The objectives of this research are to 1) Formulate equation that shows the effect of pore aperture (or confinement) on not just the mass movement of molecules but the movement of individual molecules and 2) elucidate the derived equation and illustrate with diameter...
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Research Article10.9734/AJOPACS/2018/41975
Objectives: The purposes of this research are 1st, to show that there is a relationship between magnetic constant and Bohr radius for any atom and 2nd, to verify this relationship with illustrative calculations. Place and Duration of Study: Department of Chemistry and Biochemistr...
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Research Article10.9734/AJOPACS/2018/41232
Objectives: The objectives of this research are 1) to examine the units of parameters in quasi-steady state approximation (QSSA) equations (inequalities) with a view to confirming or otherwise the dimensional consistency, 2) to slightly modify the general equation of rate constan...
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Research Article10.9734/AJOPACS/2018/40904
Aims: The aims of the research were 1), to derive simple equations that can be used to determine mass concentration of reaction mixture components, and 2), to determine the mass concentration of free substrate, total mass concentration of substrate involved in enzyme-substrate co...
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Research Article10.9734/IJBCRR/2017/35040
Aims: i) To show that attractive electrostatic interaction is essential to stable enzyme-substrate formation, ii) to determine the minimum interparticle distance for maximum attractive interaction, iii) to determine the duration and the velocity of transit before enzyme substrate...
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Research Article10.9734/AIR/2017/32676
Aims: 1) To formulate models based on defined principle for the application of Fitter’s model and 2) ultimately show that there are changes in the radius of an enzyme in solution and consequently conformational entropy change with temperature before and during catalytic activity....
Open access
Research Article10.9734/IJBCRR/2017/31097
Aims: The objectives of the research were (i) to show that the mass concentration, molar mass of one-active site enzyme, and consequently, the type of human salivary alpha amylase (HSαA), can be determined using kinetic parameter dependent model, (ii) to show that the free energy...
Open access
Research Article10.9734/JSRR/2016/29395