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Clinical pharmacology

Papers (37)

Administration of High-Risk Medication: A Hospital Based Prospective Study

Seema Bansal, Rajeev Chowdary, Prakashchand Shrama & Dawn V. Tom · Asian Journal of Medicine and Health · 2022

Background: High-risk medicines are outlined as those medicines that have a high risk of inflicting pain or death once employed to patients in error. Hence, this work was done to identify key parameters of mishandling observed by the administration on high-risk medication. Method...

Open access Research Article 10.9734/ajmah/2022/v20i530464

HPTLC Densitogram Profile of Aqueous Distillate (Arka) from Roots of Boerhaavia diffusa

Pooja, V Lal & A Verma · British Journal of Pharmaceutical Research · 2016

The aqueous distillate (arka) of Boerhaavia diffusa was prepared and investigated qualitatively for TLC. The following work constitutes the enrichment of constituents present in the aqueous distillate (arka) by partition technique using various solvents such as toluene and ethyl...

Open access Research Article 10.9734/bjpr/2016/19399

Molecular Mechanisms of the Modulatory Effect of Vitamin E on Tacrolimus (FK506)-Induced Renal Injury in Rats

Hassan Afify, Abdel-Aziz Abdel-Aziz, Mahmoud El-Din, Amany Balah & El-Sayed Akool · British Journal of Pharmaceutical Research · 2016

Aim: This study was designed to evaluate the possible modulatory effect of vitamine E on tacrolimus (FK506)-induced renal injury in rats. Methods: Twenty-four male Wistar rats (6 animals in each group) were used in this study. The first group (Control) received normal saline intr...

Open access Research Article 10.9734/bjpr/2016/21684

Melatonin Improves Metabolic Abnormalities Induced by HAART in Mice

J Borges, T Jr, L Ciupa, M Jr & A Pupulin · British Journal of Pharmaceutical Research · 2016

Aims: Highly Active Antiretroviral Therapy (HAART) is associated with metabolic complications. An unexpected extension of functional implications of melatonin, the neuro-hormone synthetized during the night, has been reported on the development of type 2 diabetes, sleep disturban...

Open access Research Article 10.9734/bjpr/2016/29474

Anti-inflammatory Effects and Acute Toxicity of Methanol Stem Bark Extract of Morus mesozygia Stapf.

Kudirat Oshiomah, Oyinlade Odujoko & Abayomi Ajayi · British Journal of Pharmaceutical Research · 2016

Aim: Morus mesozygia is a specie of the Morus family in Africa that is traditionally used for the treatment of rheumatism. Until this moment, there is no available literature on the scientific evidence of the in vivo anti-inflammatory effects. The aim is to determine the safety o...

Open access Research Article 10.9734/bjpr/2016/28746

Formulation Development and Optimization of Ibuprofen Poloxamer Melt Granules Using Hydrophilic Excipients

Bhavin Gajera, Rohit Dugar & Rutesh Dave · British Journal of Pharmaceutical Research · 2016

The focus of this research work was to develop a melt granulation technique to enhance solubility, dissolution rate and associated flowability concerns of Ibuprofen. Hydrophilic excipients like xylitol and lactose anhydrous were added to the binary mixture of conventional low mel...

Open access Research Article 10.9734/bjpr/2016/29048

HPLC, Densitometric and Visible-Spectrophotometric Determination of Triclabendazole and Ivermectin

Sawsan Razeq, Asmaa El-Demerdash & Hoda El-Sanabary · British Journal of Pharmaceutical Research · 2016

Two methods were developed for simultaneous determination of triclabendazole and ivermectin, in addition to a Vis-spectrophotometric method for the analysis of ivermectin only. The first one was HPLC method in which efficient separation of two drugs was achieved on a C18 column w...

Open access Research Article 10.9734/bjpr/2016/29196

Evaluation of C. cassia Effectiveness in Behavioral Modulation of Haloperidol Induced Parkinson’s Disease (Mice Model)

Awais Zaidi, Tanveer Khan, Lubna Shakir, Mahtab Khan, Muhammad Yousaf, Arsalan Ali, Atif Saeed & Zaka-Ur-Rehman · British Journal of Pharmaceutical Research · 2016

Aims: This study was undertaken to evaluate the effectiveness of behavioral modulation of C. cassia extract against Haloperidol induced Parkinson’s disease (PD) in albino mice. Study Design: The study used animal models to test the effect of Haloperidol in development of PD and e...

Open access Research Article 10.9734/bjpr/2016/29286

Phytochemical and Pharmacological Profiles of the Genus Odontonema (Acanthaceae)

Lokadi Luhata, Namboole Munkombwe, Peter Cheuka & Harrison Sikanyika · British Journal of Pharmaceutical Research · 2016

Odontonema is a group of tropical plant species used in folklore medicine because of its wide range of pharmacological properties. These plants are known to be anti-bacterial, anti-inflammatory, anti-hypertensive, anti-viral, hepatoprotective, sedative and anti-oxidant. Furthermo...

Open access Research Article 10.9734/bjpr/2016/29877

Self-medication; An Emerging Trend

Asim Mehmood, Atta Ur-Rehman, Muhammad Zaman, Javed Iqbal & Syed Ul-Hassan · British Journal of Pharmaceutical Research · 2016

Self-medication involves the use of medicinal products by the individuals to treat self-recognized diseases or symptoms or the intermittent or continuous use of medication prescribed by a physician for chronic or recurrent disease or symptoms. Self-medication also involves acquir...

Open access Research Article 10.9734/bjpr/2016/30333

Antibacterial Activity of Pennisetum glaucum Crude Extracts and Pre-purified Fractions against Selected Pathogenic Microorganisms

Hellen Ndiku, Peter Mwitari, Beatrice Irungu & Chrispus Ngule · British Journal of Pharmaceutical Research · 2016

Background: Penisetum glaucum is one of the earliest indigenous food crops in East Africa. Pearl millet contains numerous phytocompounds. Isolation and characterization of secondary metabolites from pearl millet and evaluation of their bioactivity is necessary. These will act as...

Open access Research Article 10.9734/bjpr/2016/28434

In vitro Antimicrobial Activity of Fruit Pulp Extracts of Azanza garckeana (F. Hoffm.) Exell & Hillc. and Isolation of One of its Active Principles, Betulinic Acid

Y Dikko, M Khan, T Tor-Anyiin, J Anyam & U Linus · British Journal of Pharmaceutical Research · 2016

Aims: To perform anti-microbial activity guided isolation and to characterize compound(s) from fruit pulp (extracts) of Azanza garckeana. Place and Duration of Study: Department of chemistry, University of Agriculture, Makurdi, Nigeria, and University of Strathclyde in Scotland,...

Open access Research Article 10.9734/bjpr/2016/30152

Protective Effect of Alchornea laxiflora Methanolic Leaf Extract on CCL4-induced Hepatotoxicity and Reproductive Toxicity in Male Wistar Rats

E Uhunmwangho, N Rasaq & O Ojemekele · British Journal of Pharmaceutical Research · 2016

Background: Alchornea laxiflora is a medicinal plant with immense health benefits. Aim: To verify the protective effects of methanol extract of Alchornea laxiflora (MEAL) leaf on hepatotoxicity and reproductive toxicity induced by CCl4. Settings and Design: Extraction and adminis...

Open access Research Article 10.9734/bjpr/2016/29807

Silver Nanoparticles-loaded Hydrogels, A Potential Treatment for Resistant Bacterial Infection and Wound Healing: A Review

Aml Mekkawy, Mohamed El-Mokhtar, Sohair El-Shanawany & Ehsan Ibrahim · British Journal of Pharmaceutical Research · 2016

Several pathogenic bacteria are developing antibiotic resistance. Recovery from multidrug resistant (MDR) infections is a problematic issue and requires a multiple treatment with broad-spectrum antibiotics which are less effective, more toxic and more expensive. Silver nanopartic...

Open access Research Article 10.9734/bjpr/2016/30525