Anti-Inflammatory and Antitussive Activity of Asthpadose, a Phytomedicine used in the Treatment of Asthma in Côte d'Ivoire

Abstract

Introduction: The aim of this study is to contribute to the valorisation of an anti- asthmatic phytomedicine (Asthpadose) traditionally used in Côte d'Ivoire. Aims: Evalute antiasthma’s activity of the aqueous extract of Asthpadose (EAA) was. Methodology: The antiasthma’s activity of the aqueous extract of Asthpadose (EAA) was evaluated by the determining of its anti-inflammatory activity using the carrageenan oedema induction method. This anti-asthmatic activity was also evaluated by its antitussive action on the frequency of cough induced in rats exposed to liquid ammonia. Results: The results revealed that EAA showed a very significant strong anti- inflammatory activity with an oedema inhibition rate ranging from 34.29% to 70.9 5%. This activity was much better than that of diclofenac sodium (a reference molecule against inflammation) with an oedema inhibition rate ranging from 12.24% to 58.39%. As for its antitussive activity, the results also showed good antitussive activity of the extract. EAA presented a cough inhibition rate of 74.22% compared to 58.76% for dextrometaphan which is also a reference molecule against cough. Conclusion: This observed activity could therefore justify the use of Asthpadose in the treatment of asthma which is a disease manifested by inflammation and cough. In view of the very promising results of this study, it would therefore be necessary to continue studies on this phytomedicine to understand its mechanism of action on asthma.