Evaluation of the Anxiolytic Effect of Methanolic Leaves Extract of Paullinia pinnata Lin in Mice
M. Aliyu, J. A. Anuka, A. H. Yaro, M. G. Magaji
Journal of Pharmaceutical Research International · pp. 1638–1646 · Published 27 Jun 2014
10.9734/BJPR/2014/10990Abstract
This study was designed to evaluate the anxiolytic effect of methanolic leave extract of Paullinia pinnata L. in mice. The elevated plus-maze and staircase paradigm were used to assess the anxiolytic activity of the methanolic leaf extract of Paullinia pinnata and diazepam. The results of the elevated plus-maze test showed that the extract at the dose of 50 mg/kg and diazepam significantly (P<0.05 and P<0.005) increased both the number of entries and time spent in the open arm by mice. In staircase paradigm, the extract produced a significant (P<0.05-P<0.0005) dose dependent decrease in the number of steps ascended and number of rearing events compared to the control mice. Diazepam significantly (P<0.0005) reduced the number of rearing events compared to control. The result of the present preliminary study suggests that methanolic leaf extract of Paullinia pinnata may possess an anxiolytic activity.
Cited by 3
Lateef Abiola Akinpelu, ItunuOluwa Michael Akanmu, Moses Atanda Akanmu · Trends in Natural Product Research · 2025
Maximilienne Ascension Nyegue, Alian Désiré Afagnigni, Youchahou Njankouo Ndam · Journal of Evidence-Based Integrative Medicine · 2020
Alian Désiré Afagnigni, Maximilienne Ascension Nyegue, Steve Valdi Djova · Journal of Tropical Medicine · 2020
Related research
- Comparison of the Effectiveness of Intravenous Promethazine and Intravenous Diazepam in the Treatment of Benign Paroxysmal Positional Vertigo in the Emergency Department — shares topic coverage
- Effects of Lignocaine-Diazepam Combination in Lumbo-Sacral Epidural Anaesthetized Dogs Undergoing Caudectomy — shares topic coverage
- Kinetics of Oxidation of Diazepam by N Bromosuccinimide in Acid Medium: A Mechanistic Study — shares topic coverage
- Acute and Sub-Acute Evaluations of Parsonsia straminea Stem Bark Ethanol Extract Impact on Some Behavioral Parameters in Mice — shares topic coverage
- The Haematotoxicity and Nephrotoxicity Effects of Diazepam Administration in Male Albino Rats — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
3
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.