Aims: Hydroalcoholic T. dodoneifolius, B.pinnatum and T. catappa leaf extracts were investigated for their acute toxicity and anxiolytic activities. Study Design: Acute toxicity (LD50) was determined using the limit dose acute and Anxiolytic activities were assessed by open-field...
Open access
Research Article10.9734/indj/2023/v19i3374
The high prevalence and disease burden of anxiety disorders against the paucity and liabilities of existing anxiolytics indicates a need for the discovery of additional/new anti-anxiety agents. However, it is necessary to further screen these new/putative anxiolytic compounds/ext...
Open access
Research Article10.9734/indj/2020/v14i230123
Similar pharmacodynamic mechanism(s) often underlie drug actions and toxicities of anxiolytic agents and medicinal extracts. Extracts of Tapinanthus globiferus and related plant species have been reported with anxiolytic activities. But mechanistic evaluations on these plant extr...
Open access
Research Article10.9734/jocamr/2020/v10i130153
The use of test batteries has been suggested as a means to enhance throughput, to broaden the spectrum of anxiety parameters detectable and to minimise the numbers of experimental animals required in behavioural studies. This study was undertaken to determine the sensitivity of t...
Open access
Research Article10.9734/jamps/2020/v22i430166
This study was designed to evaluate the anxiolytic effect of methanolic leave extract of Paullinia pinnata L. in mice. The elevated plus-maze and staircase paradigm were used to assess the anxiolytic activity of the methanolic leaf extract of Paullinia pinnata and diazepam. The r...
Open access
Research Article10.9734/BJPR/2014/10990
Aims: The study aimed to phytochemically investigate the n-butanol soluble fraction of Indigofera hirsuta aerial parts and to evaluate the anti-inflammatory activity of the fraction using laboratory animal models. Study Design: Isolation and elucidation of the bioactive compounds...
Open access
Research Article10.9734/BJPR/2013/3609