Effects of Opium Addiction on Some Biochemical Parameters in Diabetic Rats

Abstract

These days, opium consumption has increased among people. Opium latex contains approximately 12% of the analgesic alkaloid morphine, which is processed, chemically to produce heroin and other synthetic opiates for medicinal use and for the illegal drug trade. This study was carried out to study the effect of opium on biochemical parameter changes of kidney and liver in experimental diabetic animals, due to opium abuse. Twenty four albino rats were divided into three groups and traditional opium given orally (10 mg / kg B w) to all experimental rats except the control negative group, for 90 days. Diabetes mellitus was induced in adult male albino rats, using intra-peritoneal injection of 120 mg/kg BW. Blood glucose, Serum insulin, Total protein, Urea, Creatinine, Alanine aminotrasferase (ALT), Aspartate aminotransferase (AST), Triglycerides (TGs), Total cholesterol, were measured. The data showed that, there was a decrease in levels of serum total protein, ALT, AST cholesterol and triglycerides in diabetic addicted animals compared to non-addicted diabetic animals, while creatinine and urea in addicted diabetic animals were higher. The results showed that, opium increase serum insulin and decreases serum glucose, but not significant, this due to metabolic disorders in diabetic animals. These results proved that opium reduces blood glucose in diabetic animals, but the mechanism of this effect is unclear.