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Research Article Open access CC BY 4.0

Phytoestrogens from Clinical Nutrition and Food Science Prospective

Faiza Nouh, Salima Elfagi, Mohamed H Buzgeia

Asian Journal of Food Research and Nutrition · pp. 1268–1280 · Published 3 Oct 2025

10.9734/ajfrn/2025/v4i4326

Abstract

Phytoestrogens are a group of plant-derived chemical compounds produced naturally by a number of edible plants. Phytoestrogens are substances with large pharmacological and nutritional effects that are still unused widely and properly. Phytoestrogens mimic the effects of human's estrogen. Phytoestrogens can act as both agonists and antagonists of estrogen receptors, depending on the endogenous estrogen levels and type of receptor. Phytoestrogens found in foods such as flaxseeds, soybeans, and sesame seeds.  Phytoestrogens have been shown to have various health effects, including potential benefits for bone density, cardiovascular health, and menopausal symptoms. Literatures suggest that phytoestrogens may have therapeutic applications in managing conditions such as rheumatoid arthritis, osteoporosis, and certain types of cancer. However, their effects can vary depending on factors such as duration of consumption, dosage, and individual differences in metabolism. The key point of this review is to enhance the importance of the analysis of the effect of phytoestrogens on the human body. This review also will shade the light on the chemistry, classification, biosynthesis, and potential health effects of phytoestrogens, as well as their possible therapeutic applications and food analytical techniques for detection.

Phytoestrogens chemical structure health benefits therapeutic applications food

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