Evaluation of Fleurya aestuans Extract against Brewer’s Yeast and Egg Albumin Induced Pyrexia and Inflammation

Abstract

The goal of this study is to see if hydroethanolic extract of Fleurya aestuans can reduce pyrexia and inflammation in Wistar rats. 50 study animals were divided into two groups: Pyrexia group (1, 2, 3, 4) and Inflammatory group (A, B, C, D and E). Fever was produced in the research animals by injecting 20 ml/kg of a 20% brewer's yeast suspension in normal saline under the skin. All rats had their rectal temperatures measured at hourly intervals for four days in a row. Acute inflammation was produced in the anti-inflammatory trial groups by injecting 0.1 ml of egg albumin sub-plantarly into the left hind paw. At 30, 60, 90, and 120 minutes after induction of inflammation, the circumference of the paw was measured with a Vernier caliper. In comparison to the control group (CG) and positive control group (PCG), low dose extract group (LDEG), medium dose extract group (MDEG), and high dose extract group (HDEG) showed significant reductions (p<0.05) in rectal temperatures and hind paw circumference. Finally, the hydroethanolic extract of the leaves of Fleurya aestuans was concluded to possess antipyretic and anti-inflammatory properties.