Vaccine and Adjuvant Mediated Autoimmunity

Abstract

The macrophage, natural killer cells, B and T cells are the outstanding formed elements of human immune system. In normal immune homeostatic state these cells in a way or other recognize the host body components as self via the immune surveillance mechanisms. Though when there was a shift in immune homeostasis due to  chronic induction by; i - environmental stimulus, ii –interplay of predisposing genetic elements, iii-family history, iv – bystander pathologic inflammatory system .Immune cells becomes prone to recognize the impart self or self as a non-self with subsequent induction of autoimmune diseases. The present opinion paper was aimed at vaccine and adjuvant mediated autoimmune diseases. Timelines for vaccine and adjuvant induced autoimmunity were made. Different human approved vaccines induce different autoimmune disease, more than on vaccine may induce same autoimmune disease. Shoenfeld Syndrome, the adjuvant induce autoimmune/ inflammatory syndrome. Under the umbrella of this syndrome five conditions grouped as; i – Postvaccination with an adjuvanated vaccine, ii – macrophagic myofasciitis, iii – sick building disease condition iv – Gulf war disease condition and v – siliconosis. Protocol for the practical evaluation of these diseases was suggested. Understanding Shoenfeld Syndrome is crucial for producing vaccines with a safer side effect profile.