Anti HIV-1 Activity of the Crude Extracts of Guaiacum officinale L. (Zygophyllaceae)
Henry I. C. Lowe, Ngeh J. Toyang, Alonso Heredia, Charah T. Watson, Joseph Bryant
European Journal of Medicinal Plants · pp. 483–489 · Published 16 Jan 2014
10.9734/EJMP/2014/7343Abstract
Aim: Jamaica is rich in medicinal plants. Guaiacum officinale is the “National Flower”, with reported uses in folk medicine for the treatment of various conditions including inflammation. In our search for plants with anticancer and anti-infective properties, we evaluated Guaiacum officinale for activity against HIV-1. Methodology: The leaf, seed and twig extracts of G. officinale were screened for anti HIV-1 properties in primary peripheral blood mononuclear cells (PBMCs) infected with the reference HIV-1 BaL strain. Results: All the tested extracts inhibited HIV-1 p24 production by infected cells, with EC50 concentrations of 22.35µg/ml, 23.42µg/ml and 25.04µg/ml, respectively for the leaf, seed and twig extracts. As comparison, Betulinic acid had an EC50 value of 27.50µg/ml. The tested extracts had IC50/EC50 selectivity index (SI) values of ≥ 3, which compared favorably to Betulinic acid SI value of 1.09. Conclusion: The results of this study suggest that extracts of G. officinale may provide leads for the discovery of new drug agents against HIV-1.
Cited by 7
Cherry-Ann Smart · IFLA Journal · 2019
Vijetha Pendyala, Vidyadhara Suryadevara, Subbarao Jampani · Asian Journal of Organic & Medicinal Chemistry · 2019
Henry Lowe, Blair Steele, Joseph Bryant · 2020
Ponnekanti Sandeep, Michael Helan Soundra Rani, Mohammed Nazneen Bobby · Journal of Herbs, Spices & Medicinal Plants · 2024
Suthira Maneechai, Vachiraporn Pikulthong · Pharmacognosy Journal · 2017
Henry Lowe, Blair Steele, Joseph Bryant · Molecules · 2021
Zhibin Wang, Yaodan Chang, Feng Cao · Acta Chromatographica · 2023
Related research
- Review: Parkia speciosa as Valuable, Miracle of Nature — shares topic coverage
- Nutrient Analysis and Antimicrobial Activities of the Leaves and Fruit Pulp Extracts of Tetrapluera tetraptera on Clinical Bacteria Isolates — shares topic coverage
- Anti-viral Activity Evaluation of Selected Medicinal Plants of Nigeria against Measles Virus — shares topic coverage
- Antioxidant Status, Organ Integrity and Lipid Profile of Carbon Tetrachloride Intoxicated Rats Following Pre-treatment with Methanolic Extract of Crossopteryx febrifuga Benth Leaf — shares topic coverage
- Spatial Specificity of Antioxidant Capacity Assay in Five Varieties of (Moringa oleifera) Leaves Extracts — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
7
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.