Therapeutic Targets In Breast Cancer Signaling: A Review
Emmanuel I. Obeagu, Quratulain Babar, C. C. N. Vincent, Chikwendu Lawrence Udenze, Richard I. Eze, Chukwum J. Okafor, Bart I. Ifionu, Augustine Amaeze Amaeze, Florence Ngozi Amaeze
Journal of Pharmaceutical Research International · pp. 82–99 · Published 13 Dec 2021
10.9734/jpri/2021/v33i56A33889Abstract
For women, the most dominant type of cancer is breast cancer and perhaps one of the most recognizedreasons of death. This is a disorder of many distinct traits, many of which are known as positive hormone receptor, human epidermal receptor-2 (HER2+), and three negative breast cancers (TNBC). Drugs that directly target and kill tumors constitute a rapidly-growing form of molecular therapy for cancer patients. Analysis reveals that stable breast tissue cells exhibit receptors which aren't usually present. As a result, it is imperative to cognize the molecular roots of breast cancer and the myriad compromised pathology-related processes and pathways to ensure progresses in early diagnosis and prevention. This study demonstrates essential cellular pathways relevant for breast cancer including improvements in cell proliferation, apoptosis, and hormone balances in breast tissues. On the basis of these notions, we consider how breast cancer is associated to the creation of potentially therapeutic interventions and predictive biomarkers.
Cited by 63
Vania S. Tshimweneka, Thandi V. Mhlanga · International Journal of Molecular Sciences · 2025
Aleksandar Lazovic, Bojana Simović Marković, Irfan F. Corovic · Biomedicine & Pharmacotherapy · 2025
Rahaf M Ahmad, Noura Al Dhaheri, Mohd Saberi Mohamad · Computational and Structural Biotechnology Journal · 2025
Ritika Ritika, Sonam Rani, Rishabha Malviya · Revista de Senología y Patología Mamaria · 2025
Yifu Chang, Jianwei Zhong, Yue Quan · ACS Sensors · 2025
Sára Garai, Johanna Törzsökné Márton, Melinda Csima · Healthcare · 2025
Ghosoon Albahri, Adnan Badran, Heba Hellany · International Journal of Molecular Sciences · 2025
Fatemeh Rezaei, Afrooz Mazidimoradi, Zahra Pasokh · Indian Journal of Gynecologic Oncology · 2025
Solange Kolie, Pınar Altın Çelik, Hamiyet Dönmez‐Altuntaş · Bütünleyici ve Anadolu Tıbbı Dergisi · 2025
Arangasamy Mounica, Balasubramani Saveetha, Arumugam Madan kumar · Chemistry - An Asian Journal · 2025
Showing 34 of 63 known citations — external sources report more than can currently be individually listed.
Related research
- Computed Tomography Imaging Features of Chronic Headaches in Abuja, Nigeria — shares topic coverage
- Colorectal Cancer Risk and Prevention Knowledge among Adults Attending Public Health Facilities in Obudu, Cross River State, Nigeria — shares topic coverage
- Evaluation of Histopathological Diagnosis and Determination of Grades and Stages in Breast Cancer — shares topic coverage
- Emerging Technologies in Ovarian Cancer: Advancements in Treatment Strategies — shares topic coverage
- Osteogenic Osteosarcoma of the Orbit: A Case Report — shares topic coverage
Article metrics
Real usage data collected on this platform.
3
Page views
0
PDF downloads
0
Outbound clicks
63
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.