Therapeutic Potentials of Phytochemicals in Combatting Antimicrobial Resistance (AMR)

Abstract

Antimicrobial resistance (AMR) is a grave threat to global health that is made worse by the abuse and excessive use of antibiotics. This review looks into the processes of this bacterial resistance, particularly efflux pump systems, and calls for the consideration of alternative approaches. The antimicrobial plant derived bioactive compounds, rich in phytochemicals, are of significance as they can serve to mute the resistance mechanisms. Some of the core active compounds such as flavonoids, alkaloids, phenolics, and essential oils have been proven to work on some multi-drug resistant pathogens Among other things, this review also discusses how phytochemicals interact with ordinary antibiotics to improve drug effectiveness while minimizing the chances of resistance. The case studies emphasized suggest that plant derived antimicrobials are potent tools in the fight against AMR. In conclusion, the results emphasize the need for the incorporation of phytochemicals within modern treatment approaches in order to curb the problems of AMR in the world.