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Research Article Open access CC BY 4.0

The Role of GTF2H1 and SULF1 Gene Polymorphisms in T2DM

Waseem Raza, Sonia Malik, Sadaf Noor, Syeda Tahira Qousain, Syed Bilal Hussain, Syed Aun Muhammad

Asian Journal of Biochemistry, Genetics and Molecular Biology · pp. 27–36 · Published 15 Jan 2022

10.9734/ajbgmb/2022/v10i130237

Abstract

Genetic variations could be involved in the pathogenesis of diabetes. Type 2 diabetes (T2DM) accounts for 90% of all diabetes cases worldwide, however, the percentage is higher in the South Asian region. In this study, we observed the single nucleotide polymorphism (SNP) in GTF2H1 and SULF1 genes to find the association of smoking leading to T2DM. A total of 150 individuals (100 T2DM patients and 50 controls) were included in this study. Tetra ARMS-PCR was performed to study polymorphic genotyping. The data showed non-significant allelic associations of GTF2H1 rs4150558 (P=0.389228) and SULF1 rs6990375 (P=0.45124) confidence for smoking with T2DM occurrence. Both T2DM cases and controls were in Hardy–Weinberg equilibrium indicated the significant outcomes. The pooled odds ratios were calculated to evaluate the association between GTF2H4 and SULF1 polymorphisms and the risk of smoking, age, depression, energy-rich diet, obesity, and alcohol consumption adverse effects. Smoking was not found progressive risk factor of T2DM as compared to cholesterol level, depression, hormonal imbalance, healthy diet, or energy-rich diet. This study revealed that the irrational style of individuals of Southern Punjab brought a significant change in SNPs and is a greater risk for the progression of this T2DM. These molecular variants GTF2H1 and SULF1 could be used as genetic biomarkers to find the association of smoking with cancer but not with T2DM.

SNPs type 2 diabetes smoking genetic variation genotyping

References (25)

  1. 1 Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels [DOI]
  2. 2 Type 2 diabetes [DOI]
  3. 3 Genetics of Type 2 Diabetes—Pitfalls and Possibilities [DOI]
  4. 4 Environmental Risk Factors for Developing Type 2 Diabetes Mellitus: A Systematic Review [DOI]
  5. 5 Sequential Projection Learning for Hashing with Compact Codes
  6. 6 Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes [DOI]
  7. 7 Diabetes Prevalence Survey of Pakistan (DPS-PAK): prevalence of type 2 diabetes mellitus and prediabetes using HbA1c: a population-based survey from Pakistan [DOI]
  8. 8 Relationships Among Insulin Resistance, Type 2 Diabetes, Essential Hypertension, and Cardiovascular Disease: Similarities and Differences [DOI]
  9. 9 Type 2 diabetes mellitus in Pakistan: Current prevalence and future forecast.
  10. 10 Impact of Demographic, Socioeconomic, and Psychological Factors on Glycemic Self-Management in Adults with Type 2 Diabetes Mellitus [DOI]
  11. 11 Common Genetic Variants and Risk for HPV Persistence and Progression to Cervical Cancer [DOI]
  12. 12 Primer1: Primer Design Web Service for Tetra-Primer ARMS-PCR [DOI]
  13. 13 Impact of cigarette smoking in type 2 diabetes development [DOI]
  14. 14 Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease [DOI]
  15. 15 The Association between Type 2 Diabetes Mellitus and Women Cancer: The Epidemiological Evidences and Putative Mechanisms [DOI]
  16. 16 Fatigue in Type 2 Diabetes: Impact on Quality of Life and Predictors [DOI]
  17. 17 Does depression increase the risk of developing type 2 diabetes? [DOI]
  18. 18 Smoking, Smoking Cessation, and Risk for Type 2 Diabetes Mellitus: A Cohort Study [DOI]
  19. 19 Genetics of type 2 diabetes mellitus and obesity—a review [DOI]
  20. 20 The role of insulin resistance in experimental diabetic retinopathy—Genetic and molecular aspects [DOI]
  21. 21 Genome-wide association scans for Type 2 diabetes: new insights into biology and therapy [DOI]
  22. 22 International Journal of Environmental Research and Public Health [DOI]
  23. 23 The Health Consequences of Smoking -- 50 Years of progress: A Report of the Surgeon General [DOI]
  24. 24 Global Prevalence of Diabetes: Estimates for the Year 2000 and Projections for 2030 [DOI]
  25. 25 Detecting Undiagnosed Type 2 Diabetes: Family History as a Risk Factor and Screening Tool [DOI]

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