Tapentadol Nasal Spray is an Effective Way of Pain Management after Tooth Extraction: A Randomized Control Clinical Trial

Abstract

Background: Tapentadol nasal spray (Tapease NS) application is a novel method of pain management attributable to its action on higher centers for pain management in contrast to non-steroidal analgesics. The study aims to compare the efficacy of post-extraction pain control between Tapentadol nasal spray and oral administration of Diclofenac (50mg tablet). Methodology: Fifteen subjects (30 sides) between the age group of 18-50 years with bilateral extraction of teeth were randomly selected for the study. Tapentadol nasal spray [22.5mg x 2=45mg] was administered on the right side every 8 hourly. The second extraction was done after 7 days on the left side and administered Diclofenac tablet at eight hourly intervals. Both groups received the therapy drugs for 3 days and the pain was assessed using the pain analog scale in both cases. Results: The subjects administered with Tapentadol nasal spray did not experience any pain and controlled group receiving the Diclofenac tablet experienced pain and were administered with rescue analgesics. Conclusion: Tapentadol nasal spray demonstrated a favorable outcome compared to the Diclofenac tablet in managing post-extraction pain. Hence, the proposed Tapentadol nasal spray is an optimal choice of analgesia recommended over other forms of oral analgesia post-extraction determined through thorough evaluations and approved questionnaires received from patients.