Synthesis, Anti Cancer and Anti Fungal Studies of New Phenyl Ethylene Derivatives
V. S. R. N. Phanikumar, M. Kiranmai Reddy, G. Veera Raghava Sharma
Journal of Pharmaceutical Research International · pp. 1737–1742 · Published 23 Dec 2021
10.9734/jpri/2021/v33i60B34801Abstract
Synthesis of Phenyl ethylene derivatives (4a-4f ) are reported in this communication. Products were characterized by1HNMR, Carbon (13C) NMR and Mass spectral data. Synthesized compounds of 4a-4f were screened for anti cancer and anti fungal activities and their results are presented. The main intermediate (3) was prepared from 4-methoxy phenyl acetone (1) reacted with aqueous ethylamine and NaBH4 to get the compound (2).Further dehydrohalogenation of (2) with 4-bromobutanol and potassium carbonate at 80°C resultedin compound (3)which on further dehydration with p-toluene sulfonic acid under reflux conditionsgave 4a to 4f.
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