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Research Article Open access CC BY 4.0

Synthesis and Antibacterial Potency of Some 3-methyl-2-oxo-1,2-dihydroquinoxaline-6- sulfonohydrazone Derivatives

Festus O. Taiwo, Olawatayo E. Abioye, Craig A. Obafemi, David A. Akinpelu

Journal of Advances in Microbiology · pp. 56–70 · Published 13 Dec 2023

10.9734/jamb/2023/v23i11779

Abstract

Studies on the synthesis of some sulfa quinoxaline has generate a considerable reputation as a result of their outstanding biochemical properties. This recent study was designed to prepared some sulfa quinoxaline hydrazone derivatives and studying their antimicrobial potency. The 3-methyl-2-oxo-1,2-dihydroquinoxaline-6-sulfonohydrazone derivatives were synthesized by the reactions of 3-methyl-2-oxo-1,2-dihydroquinoxaline-6-sulfonohydrazide and six substituted benzaldehydes and examined for their possible antibacterial potency. The synthetic compounds exhibited wide-ranging spectrum action counter to twenty-four bacteria strains with minimum inhibitory concentrations values 0.0313 - 0. 250 mg/mL.  This is a suggestion that such compounds could be used to formulate antibiotics to circumvent the problem of increasing resistance by pathogens to the existing synthetic antibiotics.

3-methyl-2-oxo-1,2-dihydroquinoxaline-6-sulfonohydrazide quinoxaline hydrazones antibacterial activity quinoxaline-2,3-dione synthesis

References (16)

  1. 1 THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY [DOI]
  2. 2 Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors [DOI]
  3. 3 Structure revision of the antibiotic echinomycin [DOI]
  4. 4 Growing Problem of Multidrug-Resistant Enteric Pathogens in Africa [DOI]
  5. 5 Antitumoral activity of quinoxaline derivatives: A systematic review [DOI]
  6. 6 Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues [DOI]
  7. 7 Design and synthesis of antituberculars: preparation and evaluation against Mycobacterium tuberculosis of an isoniazid Schiff base [DOI]
  8. 8 Synthesis of certain substituted quinoxalines as antimicrobial agents (part II) [DOI]
  9. 9 2,3-Bifunctionalized Quinoxalines: Synthesis, DNA Interactions and Evaluation of Anticancer, Anti-tuberculosis and Antifungal Activity [DOI]
  10. 10 Recognition elements that determine affinity and sequence-specific binding to DNA of 2QN, a biosynthetic bis-quinoline analogue of echinomycin.
  11. 11 The mode of action of quinoxaline antibiotics. Interaction of quinomycin A with deoxyribonucleic acid.
  12. 12 Synthesis of New 2‐Acetyl and 2‐Benzoyl Quinoxaline 1,4‐Di‐N‐oxide Derivatives as anti‐Mycobacterium tuberculosis Agents. [DOI]
  13. 13 Synthesis of Some Quinoxaline Sulfonamides as a Potential Antibacterial Agent [DOI]
  14. 14 Design, Synthesis and Antibacterial Activity of some 3,6-Dimethlyquinoxaline-2-Hydrazone Derivatives [DOI]
  15. 15 Design, Synthesis, Reactions and Antibacterial Properties of 2-hydrazinyl-3-methyl-6-nitroquinoxaline Derivatives [DOI]
  16. 16 International Journal of Pharmacy and Technology [DOI]

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