Study of the Biological Activity of Alkyl Derivatives of Tetrahydroisoquinolines
Umida Khamidova, Ekaterina Terenteva, Mukaddas Umarova, Jaloliddin Abdurakhmanov, Sabirdjan Sasmakov, Artyom Makhnyov, Valentina Vinogradova, Abdusalom Saidov, Zaynat Khashimova, Shakhnoz Azimova
Journal of Pharmaceutical Research International · pp. 238–246 · Published 21 Oct 2021
10.9734/jpri/2021/v33i46B32938Abstract
A row of 1-alkyne (C6-C17) derivatives against tetrahydroisoquinoline have been synthesized. 1-alkyne (C6-C17) derivatives cytotoxicity against three lines of cancer cells and two lines of normal cells was studied. It was found that 1-tridecyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline exhibits a high cytotoxic effect with low toxicity to healthy cells. Antimicrobial activity of 1-alkyne (C6-C17) derivatives against 5 strains of bacteria and fungus was studied. It has been found that 1-nonyl-6,7-dimethoxy-1,3,4-tetrahydroisoquinoline exhibits strong antibacterial and antifungal effects.
Cited by 0
No indexed citations yet.
Related research
- Molecular Identification, Bioactivity Screening and Metabolic Fingerprinting of the Actinomycetes of Chenab River Sediments — shares topic coverage
- Antimalarial Efficacy of Bergenia ciliata (Saxifragaceae) Leaf Extract In vitro against Plasmodium falciparum and In vivo against Plasmodium berghei — shares topic coverage
- Anti-viral Activity Evaluation of Selected Medicinal Plants of Nigeria against Measles Virus — shares topic coverage
- In Vitro Antioxidant and In Vivo Antidiabetic Properties of Citrus Maxima Leaf Extracts in Alloxan-Induced Swiss Albino Diabetic Mice — shares topic coverage
- Cytotoxic Effects of Cadmium and Paraquat on Avian Skin Fibroblasts — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.