Study of Haematological and Biochemical Parameters of COVID-19 Patients in ICU and in Ward

Abstract

Introduction: Covid-19 is 65 nm to 125 nm in diameter and contains single-stranded RNA as nuclei content. Covid-19's global scale transmission, frequent occurrence, large number of deaths, infection and mortality among care providers, and multiplicative impact in vulnerable or sensitive groups are all major causes of concern. The clinical presentations of coronavirus disease are diverse, ranging from asymptomatic carriers to manifestations of respiratory collapse requiring mechanical ventilation and ICU support, as well as multi-organ and systemic symptoms such as sepsis, septic shock, and multiple organ dysfunction syndromes (MODS). Aim: Comparison of Haematological and Biochemical Parameters of Covid-19 Patients in ICU and in Ward. Materials and Methods: 25 patients were ICU and 25 patients were ward. Patients went directly to the Observed Treatment in the Dept. of Medicine and Dept. of Respiratory. Datta Meghe Medical College and Shalinitai Meghe Hospital and Research Centre. Results: Serum urea and creatinine significantly raised in ICU patients as compare to ward patients while sodium, potassium and chloride were insignificantly increased in ICU patients. Table 1 shows the D-dimer was also increased in ICU patients (3.45±2.76) as compare to the ward patients (1.49±2.13). D-Dimer is significantly increased in ICU patients (P=0.0071). As we can see in above table the level of Pro-BNP were highly significantly raised in ICU patients as compare to the ward patients (P = 0.0001). While level of Trop T insignificantly increased in ICU patients (P=0.8732). Conclusion: Several indicators, such as elevated leukocyte and CRP, LDH, and deranged urea/creatinine, were identified to be most likely correlated factors with disease incidence and mortality in our study. So are lower bicarbonate levels. However, acute liver and kidney injury are more common in COVID-19 patients.