Some Blood Cell Changes and Alteration in Renal and Hepatic Function in Pre-eclampsia: A Study in Owerri Nigeria
Precious Nc. Alisi, F. I. Buseri, Chinwe S. Alisi
International Blood Research & Reviews · pp. 132–139 · Published 13 Mar 2014
10.9734/IBRR/2014/3018Abstract
Aims: We studied some blood cell changes and alterations in renal and hepatic functions in pregnancy and pre-eclampsia and determined baselines for the population in owerri, south east Nigeria. Study Design: It was a cross sectional case control study conducted prospectively among antenatal women attending clinic at Holy Rosary, Federal Medical Centre and General Hospitals Owerri. The study included fifty non-pregnant, fifty pre-elampsia and fifty normotensive pregnant women of singleton gestation in their third trimester Place and Duration of Study: Sample: Antenatal unit of Holy Rosary, Federal Medical Centre and General Hospitals Owerri between May 2009 and June 2010. Methodology: The study included fifty (50) non-pregnant women, fifty (50) pregnant normotensive women and fifty (50) pre-eclamptic women of singleton gestation in their third trimester. Full blood count, liver function enzymes assay and some kidney function parameters was determined in all subjects. The subjects were selected under defined criteria. PE patients were at 28 to 42 wks of single-diastolic pressure of 110mmHg or more or two measurements of 90mmHg or more on two consecutive occasions of 6hours or more apart, urinary protein 2+ or more. The exclusion criteria include history of hypertension and proteinuria before conception or before 20wks of gestation, a history of antioxidant vitamins therapy during the last one year and smoking. Results: The result showed a significant (P = 0.05) decrease in Red cell distribution width coefficient of variance (RDW-CV), mean cell haemoglobin (MCH), platelet count (PC) and mean platelet volume- platelet count (MPV-PC) ratio in pre-eclampsia comaperd to normal pregnancy. Significant increases (P= 0.05) in red blood cell count, haemoglobin concentration, haematocrit, mean cell volume, mean platelet volume, platelet distribution width (PDW) and circulating large platelet ratio (PLCR) were found among the pre-eclamptic women. There was a significant (P = 0.05) increase in ALT, AST, ALP and LDH activities in pre-eclampsia when compared to both the normal and the pregnant controls. Urea, Creatinine and Uric acid concentrations had a significant increase (P = 0.05) in pre-eclampsia when compared to normal and pregnant controls Conclusion: The significant variation seen in these red cell parameters between the PC and NPC is attributable mainly to pregnancy than to pre-eclampsia. Pre-eclampsia though resulted in a marked platelet usage with a resulting shorter platelet life-span. A burden on the liver and kidney resulting from pre-eclampsia could have adversely affected protein metabolism which in turn may have affected erythropoesis. Results indicate that renal function is impaired in the presence of pre-eclampsia.
References (17)
- 1 A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases [DOI]
- 2 Clinical Guide to Laboratory Tests. [DOI]
- 3 THE CLASSIFICATION AND DIAGNOSIS OF THE HYPERTENSIVE DISORDERS OF PREGNANCY: STATEMENT FROM THE INTERNATIONAL SOCIETY FOR THE STUDY OF HYPERTENSION IN PREGNANCY (ISSHP) [DOI]
- 4 Thrombocytopenia at delivery: A prospective survey of 6715 deliveries [DOI]
- 5 Clinical guide to laboratory tests [DOI]
- 6 Platelet count at term pregnancy: a reappraisal of the threshold [DOI]
- 7 The use of platelet density and volume measurements to estimate the severity of pre‐eclampsia [DOI]
- 8 The effect of pre-eclampsia on complete blood count, platelet count and mean platelet volume [DOI]
- 9 Liver and kidney function tests in normal and pre-eclamptic gestation--a comparison with non-gestational reference values.
- 10 Hemostatic Function in Healthy Pregnant and Preeclamptic Women: An Assessment Using the Platelet Function Analyzer (PFA-100??) and Thromboelastograph?? [DOI]
- 11 Hemorheological changes in women with severe preeclampsia.
- 12 ▪ Platelet Count at Term Pregnancy: A Reappraisal of the Threshold [DOI]
- 13 Evaluation of the Protective Potential of Chromolaena odorata Linn. Extract on Carbon Tetrachloride-Induced Oxidative Liver Damage [DOI]
- 14 Mean platelet volume of normal pregnant women and severe preeclamptic women in Siriraj Hospital.
- 15 Thrombocytopenia at delivery: A prospective survey of 6715 deliveries [DOI]
- 16 Hemoconcentration and pre-eclampsia [DOI]
- 17 The Classification and Diagnosis of the Hypertensive Disorders of Pregnancy: Statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP) [DOI]
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