Skip to content
Research Article Open access CC BY 3.0

Some Biochemical Effects of Methanolic Extract of Afzelia africana Seed in Rats Following Single or Repeated Carbon Tetrachloride Intoxication

Uju Dorothy Iliemene, Sunday Ene-Ojo Atawodi

Biotechnology Journal International · pp. 1272–1282 · Published 30 Oct 2014

10.9734/BBJ/2014/13785

Abstract

Some Biochemical Effects of Methanolic Extract of Afzelia africana Seed in Rats Following Single or Repeated Carbon Tetrachloride Intoxication Aim: To establish the in vivo effects of the methanolic extract of Afzelia africana seed on CCl4- induced organ damage on some biochemical parameters. Methods: The rats were divided into 7 groups of 5 rats each. In the single administration experiment, rats were intraperitoneally pre-treated with the extract (10mg/kg) for two days before CCl4 intoxication at 0.6ml/kg. In the repeated intoxication experiment, rats were administered the extract (5mg/kg) by intraperitoneal injection for 10 consecutive days, and CCl4 (0.6ml/kg) 72 hourly intervals for 10 days. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin (conjugated and total) were analyzed for hepatoprotective effect, while urea and creatinine were used to evaluate kidney function. Results: Data obtained showed significant reduction (P=.05) in the activities of ALT and AST, as well as in levels of bilirubin, urea and creatinine in the Afzelia africana extract-treated rats compared to the CCl4 control. Conclusion: These results indicate that the seeds of A. africana contain constituents that could protect the kidney and liver and ameliorate them from both acute and chronic injuries.

Afzelia africana biochemical effects antioxidant oxidative stress chronic effect acute effect in vivo effect

References (13)

  1. 1 Lipid peroxidation modifies the picture of membranes from the “Fluid Mosaic Model” to the “Lipid Whisker Model” [DOI]
  2. 2 Antioxidant potential of African medicinal plants [DOI]
  3. 3 Effect of melatonin on carbon tetrachloride- induced kidney injury in wistar rats [DOI]
  4. 4 Screening of antioxidant activity and phenolic content of 24 medicinal plant extracts
  5. 5 Basic Medical Biochemistry: A Clinical Approach
  6. 6 Marks' Basic Medical Biochemistry: A Clinical Approach
  7. 7 Clinical Toxicology: Principles and Mechanisms
  8. 8 Hepatoprotective Activity of Cichorium intybus L. Leaves Extract Against Carbon Tetrachloride Induced Toxicity [DOI]
  9. 9 Physico-chemical and toxicological studies on Afzelia africana seed and oil [DOI]
  10. 10 In vitro antimicrobial and phytochemical properties of crude extract of stem bark of Afzelia africana (Smith) [DOI]
  11. 11 Polyphenol Composition and Antioxidant Potential of Hibiscus esculentus L. Fruit Cultivated in Nigeria [DOI]
  12. 12 Marks' basic medical biochemistry: A clinical approach (second edition) [DOI]
  13. 13 Lu's Basic Toxicology [DOI]

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

32

Page views

0

PDF downloads

4

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.