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Research Article Open access CC BY 4.0

Serum Copper and Serum Zinc in Preeclampsia: Cause or Effect?

Anjum A. K. Sayyed, Alka N. Sontakke

International Journal of Biochemistry Research & Review · pp. 52–57 · Published 20 Nov 2020

10.9734/ijbcrr/2020/v29i930224

Abstract

Background: Preeclampsia is multisystem disorder. Despite its prevalence and severity, the pathophysiology of this multisystem disorder is poorly understood. In concern regarding the increasing number of preeclamptic cases and lack of data about the levels of trace elements in preeclampsia, a case-control study was conducted with aim to determine the trace elements like serum total copper and serum total zinc in preeclampsia. Aims: To estimate alterations in serum copper and serum zinc in preeclampsia and to compare them with normal pregnant women. Study Design: This is a case control study, carried out in the Department of Biochemistry, MIMER Medical College, Talegaon Dabhade, Pune. Methods: The present study consisted of 120 study participants. These were divided into two groups. Group I - normal pregnant women as control (n=60) and Group II - preeclamptic group (n=60). The serum levels of copper and zinc were determined by inductively coupled plasma atomic emission spectrometry (ICP- AES) technique at IIT Mumbai. Results: Analysis revealed that mean values of total serum copper and total serum zinc were 196.20 ± 25.9 and 77.15 ± 14.5 (µg/dl) respectively in control group. In preeclamptic group, the mean values of copper and zinc were 213.13± 38.6 and 76.23 ± 13.13 (µg/dl) respectively. Copper was significantly increased in preeclamptic group, while non-significant reduction in levels of zinc levels was observed when compared to control group. Conclusion: In the present study, significantly high serum copper was observed in preeclamptic patients. Presence of high copper levels may be related factor in the etiopathogenesis of preeclampsia. Estimation of trace elements like copper and zinc may help clinicians in early diagnosis and minimizing or delaying complications of preeclampsia, hence preventing harm to both mother & fetus.

Copper zinc preeclampsia ICP- AES.

References (9)

  1. 1 Invasive Cytotrophoblasts Manifest Evidence of Oxidative Stress in Preeclampsia [DOI]
  2. 2 Trace element transfer from the mother to the newborn — investigations on triplets of colostrum, maternal and umbilical cord sera [DOI]
  3. 3 Role of trace elements zinc, copper and magnesium during pregnancy and its outcome [DOI]
  4. 4 First Trimester Serum Copper or Zinc Levels, and Risk of Pregnancy-Induced Hypertension [DOI]
  5. 5 High serum copper level is associated with an increased risk of preeclampsia in Asians: A meta-analysis [DOI]
  6. 6 Comparative study of copper, zinc, iron, ferritin, calcium and magnesium levels in pregnancy induced hypertension and normotensive primigravida mothers [DOI]
  7. 7 Serum Copper and Plasma Protein Status in Preterm Delivery [DOI]
  8. 8 A correlation of zinc and copper levels with blood pressure in normal pregnancy and preeclampsia [DOI]
  9. 9 Correlation between Serum Sodium and Potassium Levels in Preeclampsia [DOI]

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