Serum Concentrations of VCAM-1, P-Selectin, and ICAM-1 are Downregulated during CPDA-1 Storage of Whole Blood
Augustine Okereke Abani, Stella Urekweru Ken-Ezihuo, Zaccheaus Awortu Jeremiah
International Blood Research & Reviews · pp. 162–173 · Published 14 Sep 2026
10.9734/ibrr/2026/v17i4400Abstract
Background: Storage of whole blood is accompanied by biochemical and cellular changes that may alter soluble adhesion molecules. This study evaluated serum concentrations of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and P-selectin during CPDA-1 storage and examined their patterns across ABO blood groups. Methods: A longitudinal study was conducted using 40 whole-blood units from screened healthy male voluntary donors at Rivers State University Teaching Hospital, Port Harcourt, Nigeria, with 10 units each from blood groups A, B, AB, and O. Whole blood was collected into CPDA-1 bags and stored under blood-bank conditions. Adhesion-molecule concentrations were determined by enzyme-linked immunosorbent assay at serial storage intervals. Results: VCAM-1, P-selectin, and ICAM-1 concentrations generally declined with storage. By Day 22, marked reductions were evident across all blood groups. VCAM-1 and ICAM-1 concentrations were highest in blood group A and lowest in blood group O, whereas P-selectin was highest in blood group AB and lowest in blood group O. VCAM-1 showed a weak, non-significant positive correlation with P-selectin (r = 0.294, p = 0.208) and a strong positive correlation with ICAM-1 (r = 0.888, p = 0.001). Conclusion: CPDA-1 storage was associated with progressive reductions in the measured adhesion molecules. These findings characterise storage-related changes in these soluble markers within the study conditions but do not establish their clinical effects after transfusion.
References (25)
- 1 Pathophysiology of Sickle Cell Disease [DOI]
- 2 Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment [DOI]
- 3 Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer [DOI]
- 4 The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds [DOI]
- 5 Endothelial Dysfunction in Chronic Inflammatory Diseases [DOI]
- 6 ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders [DOI]
- 7 An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies [DOI]
- 8 The blood donor in sub-Saharan Africa: a review [DOI]
- 9 The physiological roles of ICAM-1 and ICAM-2 in neutrophil migration into tissues [DOI]
- 10 Platelet Inflammatory Response to Stress [DOI]
- 11 Analysis and clinical relevance of microparticles from red blood cells [DOI]
- 12 Red blood cell age determines the impact of storage and leukocyte burden on cell adhesion molecules, glycophorin A and the release of annexin V [DOI]
- 13 Innate Immune Activation After Transfusion of Stored Red Blood Cells [DOI]
- 14 Exploring donor and product factors and their impact on red cell post-transfusion outcomes [DOI]
- 15 Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets [DOI]
- 16 Effect of red blood cell transfusion on inflammation, endothelial cell activation and coagulation in the critically ill [DOI]
- 17 Storage of red blood cell concentrates: Clinical impact [DOI]
- 18 Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor Receptor [DOI]
- 19 ABO and rhesus blood groups among blood donors in Kano, North-Western Nigeria [DOI]
- 20 Aging of platelets stored for transfusion [DOI]
- 21 Analysis of the Increase of Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression and the Effect of Exposure in a Hyperbaric Chamber on VCAM-1 in Human Blood Serum: A Cross-Sectional Study [DOI]
- 22 Socio-demographic and Haematological Profile of Voluntary Blood Donors in Abakaliki, Southeast Nigeria [DOI]
- 23 Cell Adhesion Molecules [DOI]
- 24 Sociodemographic profile and characteristics of whole blood donors in a multispecialist health centre in North Central Nigeria [DOI]
- 25 Comparative Effects of ACD, CPD, and CPDA-1 on Haematological and Enzyme Parameters in Stored Blood [DOI]
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