Cystatin C, Age and Gender in Healthy African Black Adults: Ivorian Exemple

Abstract

Background: On account of the limitations of creatinine, attention has focused in recent years on cystatin C, a small protein, to be the best marker of renal function evaluation. However data by race, particularly among African black populations are rare or missing. Aim of this study was to determine in general Ivorian population, usual values of serum cystatin C according to age and gender. Materials and Methods: The study included 150 black healthy adult subjects, successively recruited at the National Blood Transfusion Center (CNTS) of Abidjan. Serum cystatin C was determined using particle-enhanced immunoassay method (PETIA). Results: Serum cystatine C ranged from 0.43 to 1.45 mg/L with a confidence interval 0.87 to 0.91 mg/L. The averages are 0,92 +/- 0,12 mg/L in men versus 0,87 +/- 16 mg/L in women. After 50 years, concentrations are 0,94 +/- 0,19 mg/L. Conclusion: It appears that the values of serum cystatin found in Ivoirian black peoples vary by age and gender. They are different from standards described in Caucasians.