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Research Article Open access CC BY 4.0

Role of Surgical Intervention in Hereditary Spherocytosis with Haemolytic Anaemia, Splenomegaly and Jaundice

K. Senthil Kumar, K. Abinaya, R. Anantharamakrishnan, K. Pranay

Journal of Pharmaceutical Research International · pp. 222–226 · Published 14 Dec 2021

10.9734/jpri/2021/v33i57A33990

Abstract

haemolytic anaemia, splenomegaly and jaundice, admitted in Chettinad hospital and research institute during one year period from  January 2019 to January 2020. Surgical intervention is indicated for selected patients with hereditary spherocytosis with haemolytic anaemia and jaundice to abate the hemolytic process after correction of anaemia with blood transfusion. Pigmented gallstones are seen in more than 50% cases for which incidence increases with severity of hemolysis and with age. Complications include aplastic anemia (most common after parvovirus B19 infection), haemolytic crisis during inter-current infection, megaloblastic crisis – during folic acid deficiency, cardiomyopathy, hematological malignancies.

Surgical management hematological malignancies hemolysis spherocytosis

References (3)

  1. 1 SABISTON TEXTBOOK OF SURGERY [DOI]
  2. 2 Clinical and hematologic features of 300 patients affected by hereditary spherocytosis grouped according to the type of the membrane protein defect [DOI]
  3. 3 Hereditary spherocytosis [DOI]

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