Role of Curcumin in Beta Thalassemia: A Review

Abstract

Beta-thalassemia is an inherited blood disorder characterized by defective beta chains of hemoglobin which often lead to the development of anemia. These patients require periodic blood transfusions to compensate for anemia. However, these transfusions often lead to complications such as iron overload. This abnormal hemoglobin can lead to anemia and cause other medical problems. Curcumin which is a polyphenol has anti-inflammatory properties and also can increase the number of antioxidants in the body. The main aim of the study is to determine the efficiency of curcumin in the treatment of β-Thalassemia. The administration of curcumin in the treatment of β-Thalassemia has aided to be beneficial. Curcumin also exhibited hepatoprotective properties as serum bilirubin decreased in the β-Thalassemia patients. Supplementation of curcumin is seen to improve insulin resistance, lipid profile, and systemic inflammation by reducing HOMA-IR, TG, TG/HDL ratio, and hs-CRP levels. Curcumin when used in the treatment for β-Thalassemia showed low or no side effects. It has powerful anti-inflammatory effects and acts as a potent antioxidant where it can neutralize the free radicals due to its chemical structure.