Skip to content
Research Article Open access CC BY 4.0

Antioxidant Protection Mechanisms in the Cardiovascular System

Baharuddin Baharuddin

Asian Journal of Medicine and Health · pp. 140–146 · Published 27 Apr 2024

10.9734/ajmah/2024/v22i61029

Abstract

The cardiovascular system, consisting of the heart and blood vessels, plays a critical role in maintaining the consistency of blood flow to supply oxygen throughout the body. Changes in the dynamics of blood flow can occur with the progression of disease exposure. Reactive oxygen species (ROS) are a major trigger for cardiomyocyte and endothelial dysfunction. Therefore, an antioxidant defense system is essential for prevention. This review aims to provide insights into the primary mechanisms of antioxidants in their role as cardioprotective agents. The human body has at least five defense mechanisms against ROS. Understanding these mechanisms will offer readers a strong perspective on the importance of sufficient antioxidants in the body to maintain cardiovascular function.

Antioxidants cardiovascular mechanisms

References (39)

  1. 1 Reactive oxygen species (ROS) as pleiotropic physiological signalling agents [DOI]
  2. 2 MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial [DOI]
  3. 3 Oxidative Stress, Antioxidant Defenses, and Damage Removal, Repair, and Replacement Systems [DOI]
  4. 4 Free Radical Properties, Source and Targets, Antioxidant Consumption and Health [DOI]
  5. 5 Oxidative Stress in Cardiovascular Diseases [DOI]
  6. 6 Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme [DOI]
  7. 7 Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms [DOI]
  8. 8 Natural antioxidants from some fruits, seeds, foods, natural products, and associated health benefits: An update [DOI]
  9. 9 Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets [DOI]
  10. 10 Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes [DOI]
  11. 11 Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies [DOI]
  12. 12 Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis [DOI]
  13. 13 Role of endothelial dysfunction in heart failure [DOI]
  14. 14 Oxidative Stress and Antioxidant Treatments in Cardiovascular Diseases [DOI]
  15. 15 Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease [DOI]
  16. 16 Free radicals for cancer theranostics [DOI]
  17. 17 Oxidative Stress, Antioxidants and Hypertension [DOI]
  18. 18 The impact of reactive oxygen species in the development of cardiometabolic disorders: a review [DOI]
  19. 19 Antioxidants and Sports Performance [DOI]
  20. 20 Targeting Metabolic Diseases: The Role of Nutraceuticals in Modulating Oxidative Stress and Inflammation [DOI]
  21. 21 Modulation of NRF2/KEAP1 Signaling in Preeclampsia [DOI]
  22. 22 Antioxidant Supplementation in Oxidative Stress-Related Diseases: What Have We Learned from Studies on Alpha-Tocopherol? [DOI]
  23. 23 Perivascular adipose tissue: Fine-tuner of vascular redox status and inflammation [DOI]
  24. 24 Molecular Mechanisms and Therapeutic Implications of Endothelial Dysfunction in Patients with Heart Failure [DOI]
  25. 25 Oxidative stress in cerebrovascular disease and associated diseases [DOI]
  26. 26 Nuts and Cardiovascular Disease Outcomes: A Review of the Evidence and Future Directions [DOI]
  27. 27 Natural Allies for Heart Health: Nrf2 Activation and Cardiovascular Disease Management [DOI]
  28. 28 Association of nanoparticles and Nrf2 with various oxidative stress-mediated diseases [DOI]
  29. 29 Potential Benefits of Nutraceuticals for Oxidative Stress Management [DOI]
  30. 30 Molecular Mechanisms of Superoxide Dismutase (SODs)-Mediated Defense in Controlling Oxidative Stress in Plants [DOI]
  31. 31 Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease [DOI]
  32. 32 Free Radicals and Obesity-Related Chronic Inflammation Contrasted by Antioxidants: A New Perspective in Coronary Artery Disease [DOI]
  33. 33 Dietary Antioxidants, Quality of Nutrition and Cardiovascular Characteristics among Omnivores, Flexitarians and Vegetarians in Poland—The Results of Multicenter National Representative Survey WOBASZ [DOI]
  34. 34 Comparison of Coenzyme Q10 (Ubiquinone) and Reduced Coenzyme Q10 (Ubiquinol) as Supplement to Prevent Cardiovascular Disease and Reduce Cardiovascular Mortality [DOI]
  35. 35 Vitamin E Supplementation and Cardiovascular Health: A Comprehensive Review [DOI]
  36. 36 Dietary antioxidants and vascular calcification: From pharmacological mechanisms to challenges [DOI]
  37. 37 The genesis of cardiovascular risk in inflammatory arthritis: insights into glycocalyx shedding, endothelial dysfunction, and atherosclerosis initiation [DOI]
  38. 38 Coenzyme Q10 in atherosclerosis [DOI]
  39. 39 Exploring the Potential Impact of Herbal Antioxidants on Human Cardiovascular Diseases [DOI]

Cited by 3

Solanum anguivi (gnangnan) as a functional food: A natural approach to hypertension management in rats

Hadja Djeneba OUATTARA, Antoine Allah ASSAMOI, Penan Patricia OULAI · GSC Biological and Pharmaceutical Sciences · 2025

Showing 2 of 3 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

111

Page views

0

PDF downloads

53

Outbound clicks

3

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.