Reproductive Toxicity of Paraquat in Male Guinea Pig (Cavia porcellus)
Boufack Judith Laure, Guiekep Nounamo Arthénice Jemina, Nantia Akono Edouard, Vemo Bertin Narcisse, Kenfack Augustave, Menkem Brice, Ngaleu Njieudeu Claude Cédric, Yidjeu Nana Ferry
Asian Journal of Research in Animal and Veterinary Sciences · pp. 66–75 · Published 2 Feb 2021
10.9734/ajravs/2021/v4i1119Abstract
Aims: This study was undertaken in order to evaluate the effects of paraquat (pesticide) on some reproductive parameters in male guinea pig. Methodology: Forty adult male guinea pigs averagely weighing 370.31 ± 39.43 g were distributed into 4 groups of 10 animals each, comparable in terms of body weight. During 42 days, each group of guinea pigs received by force-feeding either distilled water (control) or one of the following three doses of paraquat: 1.33, 2, 4 mg/kg of body weight. The effects of this pesticide were evaluted on some reproductive parameters (total cholesterol, libido, serum concentration of testosterone, weight of genital organs and characteristics of epididymal spermatozoa) and oxidative stress makers (testicular levels of MDA, SOD, CAT and GSH). Results: Results showed that the total cholesterol increased significantly (P<.05) in guinea pigs exposed to paraquat relatively to the control. Animals forced-fed with the pesticide showed a significant (P<.05) decrease in the serum concentration of testosterone and an increase in the reaction time. A significant (P<.05) rise in abnormal spermatozoa as well as a significant (P<.05) drop in sperm mobility (65.00 ± 19.58) and spermatozoa plasma membrane integrity (52.88 ± 8.22) was observed in pesticide-treated animals compared to control. The testicular level of MDA (5.35 ± 1.89) and the activities of SOD (10.13 ± 2.03) and CAT (15.26 ± 4.28) increased significantly (P<.05) in paraquat treated guinea pigs compared to control animals. The reverse was observed concerning the testicular concentration of GSH (126.11 ± 48.94). Conclusion: Paraquat has been shown to be toxic to male guinea pig, from 2 mg /kg bw through the induction of oxidative stress, thus imparing reproductive parameters.
References (54)
- 1 Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal [DOI]
- 2 Colorimetric assay of catalase [DOI]
- 3 The Generation of Superoxide Radical during the Autoxidation of Hemoglobin [DOI]
- 4 Paraquat Poisonings: Mechanisms of Lung Toxicity, Clinical Features, and Treatment [DOI]
- 5 Medical management of paraquat ingestion [DOI]
- 6 Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism [DOI]
- 7 Paraquat and Parkinson's disease [DOI]
- 8 EFFECT OF HEAT STRESS IN TROPICAL LIVESTOCK AND DIFFERENT STRATEGIES FOR ITS AMELIORATION
- 9 Inhibition of Lipid Peroxidation by Spin Labels [DOI]
- 10 Subjecting canine semen to the hypo-osmotic test [DOI]
- 11 Predictors of survival after acute paraquat poisoning [DOI]
- 12 Hepatoprotective And Antioxidant Effects Of Argyreia speciosa In Rats [DOI]
- 13 Effect of lindane on testicular antioxidant system and steroidogenic enzymes in adult rats.
- 14 Modulation of antioxidant defense system by the environmental fungicide carbendazim in Leydig cells of rats [DOI]
- 15 Effects of pirimiphos-methyl (an organophosphate insecticide) on the fertility of adult male rats. [DOI]
- 16 Size Changes in Honey Bee Larvae Oenocytes Induced by Exposure to Paraquat at Very Low Concentrations [DOI]
- 17 Arterial lactate as a predictor of mortality in emergency department patients with paraquat intoxication [DOI]
- 18 Paraquat Induces Apoptosis through a Mitochondria-Dependent Pathway in RAW264.7 Cells [DOI]
- 19 Redox status of the liver and kidney of 2,2-dichlorovinyl dimethyl phosphate (DDVP) treated rats [DOI]
- 20 Abnormal pancreatic enzymes and their prognostic role after acute paraquat poisoning [DOI]
- 21 Acute kidney injury following Paraquat poisoning in India.
- 22 Effects of pyrethroid insecticide ICON (lambda cyhalothrin) on reproductive competence of male rats.
- 23 Clinical features, treatment, prognosis, and mortality in paraquat poisonings: A hospital-based study in Iran [DOI]
- 24 Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD [DOI]
- 25 A novel simple risk model to predict the prognosis of patients with paraquat poisoning [DOI]
- 26 Insecticides as Tools in Probing Vital Receptors and Enzymes in Excitable Membranes [DOI]
- 27 Intravenous Paraquat Poisoning [DOI]
- 28 Spermatotoxic effects of carbaryl in rats [DOI]
- 29 Higher testosterone levels are associated with increased high-density lipoprotein cholesterol in men with cardiovascular disease: results from the Massachusetts Male Aging Study [DOI]
- 30 Pesticide Exposure and Head and Neck Cancers: A Case-Control Study in an Agricultural Region. [DOI]
- 31 Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning [DOI]
- 32 Reproductive toxicity of acetamiprid in male Guinea pig (Cavia porcellus) [DOI]
- 33 The Protective Effect of Aspirin Eugenol Ester on Paraquat-Induced Acute Liver Injury Rats [DOI]
- 34 Biochemical and histopathological changes induced by different time intervals of methomyl treatment in mice liver [DOI]
- 35 Octreotide alleviates pancreatic damage caused by paraquat in rats by reducing inflammatory responses and oxidative stress [DOI]
- 36 Investigation of simple, objective, and effective indicators for predicting acute paraquat poisoning outcomes [DOI]
- 37 Hyperamylasemia as an early predictor of mortality in patients with acute paraquat poisoning [DOI]
- 38 Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus) [DOI]
- 39 Pharmacological Inhibition of CXCR2 Chemokine Receptors Modulates Paraquat-Induced Intoxication in Rats [DOI]
- 40 Paraquat Preferentially Induces Apoptosis of Late Stage Effector Lymphocyte and Impairs Memory Immune Response in Mice [DOI]
- 41 SEMEn cHArActErIStIcS And PLASMA tEStoStEronE oF nEW-ZEALAnd MALE rABBItS AS AFFEctEd BY EnVIronMEnt AL tEMPErA turES
- 42 Mortality Analysis of Patients with Paraquat Poisoning Treated at Two University Hospitals in Shiraz, Iran [DOI]
- 43 A comprehensive effect of acephate on cauda epididymis and accessory sex organs of male rats [DOI]
- 44 Persistence of the reproductive toxicity of chlorpiryphos-ethyl in male Wistar rat [DOI]
- 45 Serum total antioxidant statuses of survivors and nonsurvivors after acute paraquat poisoning [DOI]
- 46 Correlation between sperm characteristics and testosterone in bovine seminal plasma by direct radioimmunoassay [DOI]
- 47 The significance of serum HMGB1 level in humans with acute paraquat poisoning [DOI]
- 48 Paraquat Poisoning Management in Iran (Isfahan): Devising a Protocol [DOI]
- 49 Effects of paraquat in the reproductive function and on redox state of adult male rats [DOI]
- 50 Author response: Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut [DOI]
- 51 Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal [DOI]
- 52 Review of medical physiology [DOI]
- 53 Paraquat Reduces the Female Fertility by Impairing the Oocyte Maturation in Mice [DOI]
- 54 Journal of Advances in Medicine and Medical Research [DOI]
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