Skip to content
Research Article Open access CC BY 4.0

Atherogenicity, Oxidative Stress, Heavy Metals and Bioelements Status in Hypertensive Nigerians in an Urban Population

Oyedeji Samuel Oyewole, Adesina Adeyemi Adeleke, Oke Olusegun Taiwo, Adeosun Oyebola Ganiyu, Awe Kunle

Asian Journal of Medicine and Health · pp. 184–193 · Published 28 Oct 2023

10.9734/ajmah/2023/v21i11934

Abstract

Objectives: This study investigated levels of measured parameters; bio-elements (zinc, copper, selenium, chromium, and manganese), heavy metals (cadmium and lead), oxidative stress biomarkers (vitamin C, Vitamin E, reduced Glutathione-GSH and malondialdehyde-MDA) and lipid profile (cholesterol-CHOL, triglyceride- TG, high-density lipoprotein- HDL, low-density lipoprotein- LDL and VLDL) in primary hypertensive individuals. Materials and Methods: A total of 74 confirmed hypertensive individuals (30 males, 44 females) of 30-55 years (test subjects) and 46 (22males, 24 females) age-matched apparently healthy normotensive individuals (control) were involved in this study. Atomic absorption spectrophotometer was used to determine the concentrations of bio-elements and toxic metals while spectrophotometric methods were used for the concentrations of oxidative stress biomarkers and lipid fractions. Results: Comparative analysis between test and control subjects showed significantly reduced concentrations of vitamins C and E, GSH, the bio-elements, HDL and Zinc/Copper ratio. Significantly elevated concentrations of the toxic metals, MDA, CHOL, TG, LDL, and VLDL, the atherogenic indices- LDL/HDL, TC/HDL, and TG/HDL as well as Cadmium/ Zinc ratio. There was indirect association between the bio-elements and atherogenic lipid fractions but a direct correlation with HDL. Also, negative correlations were observed between the heavy metals and the antioxidants biomolecules. Conclusion: The concentrations of the measured bio-elements, vitamins C and E, GSH and HDL were significantly lower in hypertensive individuals while the levels of heavy metals, cholesterol, TG, LDL and MDA were significantly higher. 

Urban population oxidative stress heavy metals bio-elements atherogenicity hypertension vitamins

References (33)

  1. 1 A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 [DOI]
  2. 2 Global status report on noncommunicable diseases 2010.
  3. 3 Relevance, essentiality and toxicity of trace elements in human health [DOI]
  4. 4 Function and Regulation of Human Copper-Transporting ATPases [DOI]
  5. 5 Copper, Chromium, Manganese, Iron, Nickel, and Zinc Levels in Biological Samples of Diabetes Mellitus Patients [DOI]
  6. 6 Anti-oxidant status and lipid peroxidation in patients with essential hypertension [DOI]
  7. 7 Fifty years of Framingham Study contributions to understanding hypertension [DOI]
  8. 8 Serum Selenium Concentrations and Hypertension in the US Population [DOI]
  9. 9 Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits [DOI]
  10. 10 Beneficial Effect of Chromium Supplementation on Serum Triglyceride Levels in NIDDM [DOI]
  11. 11 Regional Variations of Blood Pressure in the United States Are Associated with Regional Variations in Dietary Intakes: The NHANES-III Data [DOI]
  12. 12 Decreased endogenous antioxidant enzymatic status in essential hypertension [DOI]
  13. 13 Chromium Alleviates Glucose Intolerance, Insulin Resistance, and Hepatic ER Stress in Obese Mice [DOI]
  14. 14 Serum selenium and coronary heart disease risk factors in southern Italian men [DOI]
  15. 15 Mineral Factors Controlling Essential Hypertension—a Study in the Chandigarh, India Population [DOI]
  16. 16 Prevalence of Hypertension among Urban Slum Dwellers in Lagos, Nigeria [DOI]
  17. 17 Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies [DOI]
  18. 18 Association between serum manganese levels and diabetes in Chinese adults with hypertension [DOI]
  19. 19 Blood pressure, dietary fats, and antioxidants [DOI]
  20. 20 Lipid-lowering effect of a dietary chromium (III)—Nicotinic acid complex in male athletes [DOI]
  21. 21 Lack of Effect of Dietary Chromium Supplementation on Glucose Tolerance, Plasma Insulin and Lipoprotein Levels in Patients with Type 2 Diabetes [DOI]
  22. 22 Natural approach to hypertension.
  23. 23 Excess Copper as a Factor in Human Diseases
  24. 24 High manganese exposure decreased the risk of high triglycerides in workers: a cross-sectional study [DOI]
  25. 25 Trace Elements and Blood Pressure [DOI]
  26. 26 Dyslipidemic hypertension: Distinctive features and cardiovascular risk in a prospective population-based study [DOI]
  27. 27 Effects of Elements in Human Blood Pressure Control [DOI]
  28. 28 Prevalence of non-communicable diseases and its awareness among inhabitants of Sokoto metropolis: outcome of a screening program for hypertension, obesity, diabetes mellitus and overt proteinuria.
  29. 29 Angiotensin-Converting Enzyme and Metals in Untreated Essential Hypertension [DOI]
  30. 30 EVALUATION OF ELEMENTS IN THE PATHOGENESIS OF HYPERTENSION IN NIGERIANS
  31. 31 Molecular Basis of Hypertension: A Systematic Review on the Role of Metal Ions for Increase Prevalence of Hypertension in India [DOI]
  32. 32 Evaluation of selected trace metals in some hypertensive subjects in a tertiary health institution in Southwest Nigeria.
  33. 33 [Determination of trace copper and zinc in hypertension complicated with hyperlipemia by atomic absorption spectrophotometry].

Cited by 0

No indexed citations yet.

Article metrics

Real usage data collected on this platform.

70

Page views

0

PDF downloads

26

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.