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Research Article Open access CC BY 4.0

Immunotherapy Strategies for Overcoming Resistant Cancers: Current Trends and Future Prospects

Rotimi Sunday Ajani

Asian Oncology Research Journal · pp. 1–9 · Published 20 Feb 2025

10.9734/aorj/2025/v8i197

Abstract

Cancer resistance to conventional therapies remains a significant challenge in oncology, leading to treatment failure and poor patient outcomes. Immunotherapy has emerged as a promising approach to overcome resistance by harnessing the body's immune system to recognize and eliminate cancer cells. This review dwelt on the mechanisms of resistance in cancer therapy, the advances in immunotherapy strategies, and how these therapies are overcoming resistance in various cancer types. It also highlighted the clinical outcomes of recent trials and explored future directions in the field.

Immunotherapy resistant cancers immune checkpoint inhibitors CAR T-cell therapy tumor microenvironment combination therapy biomarkers

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