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Research Article Open access CC BY 4.0

Premna integrifolia L. on Enzymatic Biomarkers in Atherosclerosis

S. Chitra, R. Arivukkodi, S. Gaidhani, R. Ilavarasan, K. S. Dhiman Vd

International Journal of Biochemistry Research & Review · pp. 1–9 · Published 9 Jun 2017

10.9734/IJBCRR/2017/34232

Abstract

Premna integrifolia L. belongs to family Verbenaceae and it is believed to prevent cardiovascular disease as per Ayurveda. In order to evaluate the cardiac biomarkers and treatment efficacy of hydroalcoholic extract (HAE) of root bark in atherosclerosis. Sixty Wistar rats were divided into six groups and ten animals in each group. Rats fed with high fat diet and various concentrations of HAE treatment were studied and standard drug, atorvastatin was compared with HAE. This extract showed a significant action against atherosclerosis in a dose dependent manner which was studied in terms of lactate dehydrogenase activity, HMG-CoA/Mevalonate ratio, collagen content in aorta, levels of transaminases, calcium and other marker enzymes indirectly involved in the cardio protection. Alteration in collagen deposition in aorta of histopathological evaluation was noticed in treated animals. Anti-atherosclerotic activity of HAE of P. integrifolia was due to its modulatory activity on cholesterol metabolism and our results contribute towards validation of the traditional use of P. integrifolia in high fat diet induced atherosclerosis.

HMG-CoA reductase anti-atherosclerosis collagen aorta agnimantha lactate dehydrogenase

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Cited by 2

Glutathione-redox status on hydro alcoholic root bark extract of Premna integrifolia Linn in high fat diet induced atherosclerosis model

Chitra Subramani, Arivukkodi Rajakannu, Sudesh Gaidhani · Journal of Ayurveda and Integrative Medicine · 2020

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